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Association details:
| Biomarker: | KRAS G12C |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | YL-17231 (pan-KRAS inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2627 / 11 - The small molecule KRAS inhibitor, TEB-17231, blocks tumor progression and overcomes KRASG12C inhibitor mediated resistance
Published date:
03/15/2023
Excerpt:
Further, TEB-17231 exhibited tumor growth inhibition (IC50) in KRAS-G12C Ba/F3 (14 nM) and derivative cell lines that acquired resistance to G12C inhibitor MRTX849….These properties highlight TEB-17231 as a potential clinically actionable inhibitor for the KRAS-modified tumor population