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Association details:
| Biomarker: | No biomarker |
|---|---|
| Cancer: | Lymphoma |
| Drug: | cytarabine (DNA synthesis inhibitor, DNA-directed DNAP inhibitor) + methotrexate (Dihydrofolic acid reductase inhibitor) + thiotepa (DNA synthesis inhibitor, Alkylating agent) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
PRIMARY CNS LYMPHOMA….Useful in Certain Circumstances...Consider high-dose systemic therapy with autologous stem cell reinfusion in eligible patients...High-dose MTX followed by cytarabine + thiotepa followed by carmustine + thiotepa
Secondary therapy:
TT-BCNU