[{"id":"dc4d04a6-0615-4ba1-8e7e-f73bd8437cb0","acronym":"CAAA603B12101","url":"https://clinicaltrials.gov/study/NCT05870579","created_at":"2023-05-23T16:06:09.074Z","updated_at":"2025-02-25T14:42:04.037Z","phase":"Phase 1","brief_title":"[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer","source_id_and_acronym":"NCT05870579 - CAAA603B12101","lead_sponsor":"Novartis Pharmaceuticals","biomarkers":" HER-2 • ER","pipe":" | ","alterations":" ER positive • HER-2 negative • HER-2 negative + ER positive","tags":["HER-2 • ER"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER positive • HER-2 negative • HER-2 negative + ER positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Kisqali (ribociclib) • fulvestrant • goserelin acetate • AAA603"],"overall_status":"Recruiting","enrollment":" Enrollment 48","initiation":"Initiation: 11/13/2023","start_date":" 11/13/2023","primary_txt":" Primary completion: 12/30/2026","primary_completion_date":" 12/30/2026","study_txt":" Completion: 01/26/2032","study_completion_date":" 01/26/2032","last_update_posted":"2025-02-14"},{"id":"79338594-273d-494e-87f7-273064c69e88","acronym":"NeoRay","url":"https://clinicaltrials.gov/study/NCT03872778","created_at":"2021-07-05T17:20:58.247Z","updated_at":"2024-07-02T16:35:07.550Z","phase":"Phase 1/2","brief_title":"[177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-NeoB Lesion Uptake","source_id_and_acronym":"NCT03872778 - NeoRay","lead_sponsor":"Advanced Accelerator Applications","biomarkers":" HER-2 • BRCA1 • BRCA2 • CDK4","pipe":" | ","alterations":" BRCA2 mutation • BRCA1 mutation • HR positive • HER-2 negative","tags":["HER-2 • BRCA1 • BRCA2 • CDK4"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRCA2 mutation • BRCA1 mutation • HR positive • HER-2 negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e AAA603"],"overall_status":"Recruiting","enrollment":" Enrollment 51","initiation":"Initiation: 07/24/2019","start_date":" 07/24/2019","primary_txt":" Primary completion: 11/24/2025","primary_completion_date":" 11/24/2025","study_txt":" Completion: 12/01/2026","study_completion_date":" 12/01/2026","last_update_posted":"2024-04-25"}]