[{"id":"59fe4335-1fcc-4358-b0b0-f40604168b4d","acronym":"HERKULES-3","url":"https://clinicaltrials.gov/study/NCT05039177","created_at":"2021-09-09T13:53:09.950Z","updated_at":"2025-02-25T15:19:15.517Z","phase":"Phase 1/2","brief_title":"A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies","source_id_and_acronym":"NCT05039177 - HERKULES-3","lead_sponsor":"Erasca, Inc.","biomarkers":" KRAS • BRAF • NRAS","pipe":" | ","alterations":" BRAF V600E • KRAS mutation • NRAS mutation • BRAF V600","tags":["KRAS • BRAF • NRAS"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • KRAS mutation • NRAS mutation • BRAF V600"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Erbitux (cetuximab) • Ibrance (palbociclib) • Braftovi (encorafenib) • ERAS-007"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 102","initiation":"Initiation: 09/20/2021","start_date":" 09/20/2021","primary_txt":" Primary completion: 08/01/2025","primary_completion_date":" 08/01/2025","study_txt":" Completion: 12/01/2025","study_completion_date":" 12/01/2025","last_update_posted":"2025-02-11"},{"id":"dde5d7d2-1dad-4eff-ab54-2b67e2cc553a","acronym":"HERKULES-2","url":"https://clinicaltrials.gov/study/NCT04959981","created_at":"2021-12-13T15:11:31.264Z","updated_at":"2024-07-02T16:35:42.103Z","phase":"Phase 1b","brief_title":"A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC","source_id_and_acronym":"NCT04959981 - HERKULES-2","lead_sponsor":"Erasca, Inc.","biomarkers":" KRAS","pipe":" | ","alterations":" KRAS mutation • EGFR mutation • KRAS G12C","tags":["KRAS"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • EGFR mutation • KRAS G12C"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Tagrisso (osimertinib) • Lumakras (sotorasib) • ERAS-007 • ERAS-601"],"overall_status":"Completed","enrollment":" Enrollment 24","initiation":"Initiation: 09/02/2021","start_date":" 09/02/2021","primary_txt":" Primary completion: 04/27/2023","primary_completion_date":" 04/27/2023","study_txt":" Completion: 04/27/2023","study_completion_date":" 04/27/2023","last_update_posted":"2023-07-25"},{"id":"330ac409-c653-4ffe-b5ad-e37d750b01db","acronym":"HERKULES-4","url":"https://clinicaltrials.gov/study/NCT05279859","created_at":"2022-03-15T18:52:50.830Z","updated_at":"2024-07-02T16:36:08.894Z","phase":"Phase 1b/2","brief_title":"A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic Malignancies","source_id_and_acronym":"NCT05279859 - HERKULES-4","lead_sponsor":"Erasca, Inc.","biomarkers":" FLT3","pipe":" | ","alterations":" FLT3 mutation","tags":["FLT3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e FLT3 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Xospata (gilteritinib) • ERAS-007 • ERAS-601"],"overall_status":"Withdrawn","enrollment":"","initiation":"Initiation: 03/15/2022","start_date":" 03/15/2022","primary_txt":" Primary completion: 03/01/2025","primary_completion_date":" 03/01/2025","study_txt":" Completion: 06/01/2025","study_completion_date":" 06/01/2025","last_update_posted":"2022-06-15"},{"id":"88762fb2-bc78-461a-9433-192ed0a1e084","acronym":"","url":"https://clinicaltrials.gov/study/NCT03415126","created_at":"2021-01-18T16:50:58.681Z","updated_at":"2024-07-02T16:36:43.443Z","phase":"Phase 1","brief_title":"A Study of ASN007 in Patients With Advanced Solid Tumors","source_id_and_acronym":"NCT03415126","lead_sponsor":"Asana BioSciences","biomarkers":" KRAS • HRAS","pipe":" | ","alterations":" KRAS mutation • BRAF mutation • NRAS mutation • HRAS mutation","tags":["KRAS • HRAS"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • BRAF mutation • NRAS mutation • HRAS mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ERAS-007"],"overall_status":"Completed","enrollment":" Enrollment 49","initiation":"Initiation: 01/19/2018","start_date":" 01/19/2018","primary_txt":" Primary completion: 06/30/2020","primary_completion_date":" 06/30/2020","study_txt":" Completion: 06/30/2020","study_completion_date":" 06/30/2020","last_update_posted":"2020-07-09"}]