[{"id":"877e6060-0685-49ad-bf87-696fb090b715","acronym":"","url":"https://clinicaltrials.gov/study/NCT03218826","created_at":"2021-01-18T15:52:53.855Z","updated_at":"2025-02-25T16:51:57.310Z","phase":"Phase 1","brief_title":"PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery","source_id_and_acronym":"NCT03218826","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • ER • PTEN • PIK3CB","pipe":" | ","alterations":" ER positive • HR positive • HER-2 negative • ER positive + HER-2 negative • HER-2 negative + ER positive","tags":["HER-2 • ER • PTEN • PIK3CB"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER positive • HR positive • HER-2 negative • ER positive + HER-2 negative • HER-2 negative + ER positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e docetaxel • AZD8186"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 23","initiation":"Initiation: 09/24/2018","start_date":" 09/24/2018","primary_txt":" Primary completion: 07/25/2022","primary_completion_date":" 07/25/2022","study_txt":" Completion: 10/03/2025","study_completion_date":" 10/03/2025","last_update_posted":"2025-02-04"},{"id":"39901d4d-3dee-40b7-99f7-2afa8c1da147","acronym":"","url":"https://clinicaltrials.gov/study/NCT01884285","created_at":"2021-01-18T08:27:26.840Z","updated_at":"2024-07-02T16:36:44.639Z","phase":"Phase 1","brief_title":"AZD8186 First Time In Patient Ascending Dose Study","source_id_and_acronym":"NCT01884285","lead_sponsor":"AstraZeneca","biomarkers":" HER-2 • ER • PGR • PTEN • PIK3CB","pipe":" | ","alterations":" HER-2 negative • PIK3CB mutation","tags":["HER-2 • ER • PGR • PTEN • PIK3CB"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 negative • PIK3CB mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e abiraterone acetate • AZD8186 • vistusertib (AZD2014)"],"overall_status":"Completed","enrollment":" Enrollment 147","initiation":"Initiation: 07/09/2013","start_date":" 07/09/2013","primary_txt":" Primary completion: 03/31/2019","primary_completion_date":" 03/31/2019","study_txt":" Completion: 02/07/2020","study_completion_date":" 02/07/2020","last_update_posted":"2020-05-29"},{"id":"653c069b-b3fd-4296-9ec6-b61db80cd0e9","acronym":"","url":"https://clinicaltrials.gov/study/NCT04001569","created_at":"2021-01-18T19:40:05.431Z","updated_at":"2024-07-02T16:36:58.529Z","phase":"Phase 1/2","brief_title":"AZD8186 and Paclitaxel in Advanced Gastric Cancer","source_id_and_acronym":"NCT04001569","lead_sponsor":"Seoul National University Bundang Hospital","biomarkers":" PTEN • PIK3CB","pipe":" | ","alterations":" PTEN deletion","tags":["PTEN • PIK3CB"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PTEN deletion"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e paclitaxel • AZD8186"],"overall_status":"Recruiting","enrollment":" Enrollment 49","initiation":"Initiation: 05/14/2019","start_date":" 05/14/2019","primary_txt":" Primary completion: 12/31/2021","primary_completion_date":" 12/31/2021","study_txt":" Completion: 12/31/2022","study_completion_date":" 12/31/2022","last_update_posted":"2019-06-28"}]