[{"id":"1e3be90b-cc8d-4ccf-9c21-3f3fb2a8ae0a","acronym":"SEACLIFF","url":"https://clinicaltrials.gov/study/NCT07181161","created_at":"2025-09-20T07:05:48.306Z","updated_at":"2025-09-20T07:05:48.306Z","phase":"Phase 1/2","brief_title":"Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer","source_id_and_acronym":"NCT07181161 - SEACLIFF","lead_sponsor":"AstraZeneca","biomarkers":" STEAP1","pipe":"","alterations":" ","tags":["STEAP1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e AZD9574"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 177","initiation":"Initiation: 09/22/2025","start_date":" 09/22/2025","primary_txt":" Primary completion: 01/09/2029","primary_completion_date":" 01/09/2029","study_txt":" Completion: 01/09/2029","study_completion_date":" 01/09/2029","last_update_posted":"2025-09-18"},{"id":"2da5468a-79d4-4eeb-942f-5b05fa2fb4d8","acronym":"CERTIS1","url":"https://clinicaltrials.gov/study/NCT05417594","created_at":"2022-06-14T22:56:26.797Z","updated_at":"2025-02-25T14:08:54.388Z","phase":"Phase 1/2","brief_title":"Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies","source_id_and_acronym":"NCT05417594 - CERTIS1","lead_sponsor":"AstraZeneca","biomarkers":" HER-2 • BRCA1 • BRCA2 • IDH1 • IDH2 • HRD • BRCA • RAD51C • RAD51D","pipe":" | ","alterations":" HER-2 negative • PALB2 mutation • RAD51C mutation • RAD51D mutation","tags":["HER-2 • BRCA1 • BRCA2 • IDH1 • IDH2 • HRD • BRCA • RAD51C • RAD51D"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 negative • PALB2 mutation • RAD51C mutation • RAD51D mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e temozolomide • Enhertu (fam-trastuzumab deruxtecan-nxki) • Datroway (datopotamab deruxtecan-dlnk) • AZD9574"],"overall_status":"Recruiting","enrollment":" Enrollment 490","initiation":"Initiation: 06/24/2022","start_date":" 06/24/2022","primary_txt":" Primary completion: 08/28/2026","primary_completion_date":" 08/28/2026","study_txt":" Completion: 08/28/2026","study_completion_date":" 08/28/2026","last_update_posted":"2025-02-19"}]