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Completion: 04/16/2029","study_completion_date":" 04/16/2029","last_update_posted":"2026-03-16"},{"id":"48a9756f-4a13-44e2-87fd-34412cf0be4b","acronym":"","url":"https://clinicaltrials.gov/study/NCT05990738","created_at":"2023-08-14T14:10:29.956Z","updated_at":"2025-02-25T14:09:58.704Z","phase":"Phase 1","brief_title":"DAREONTM-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent Chemotherapy","source_id_and_acronym":"NCT05990738","lead_sponsor":"Boehringer Ingelheim","biomarkers":" PD-L1","pipe":"","alterations":" ","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e topotecan • obrixtamig (BI 764532)"],"overall_status":"Recruiting","enrollment":" Enrollment 65","initiation":"Initiation: 02/14/2024","start_date":" 02/14/2024","primary_txt":" Primary completion: 01/21/2026","primary_completion_date":" 01/21/2026","study_txt":" Completion: 11/21/2026","study_completion_date":" 11/21/2026","last_update_posted":"2025-02-18"},{"id":"84573df1-6556-4bd1-8122-88ef0fa3cd96","acronym":"","url":"https://clinicaltrials.gov/study/NCT05879978","created_at":"2023-05-30T14:05:15.128Z","updated_at":"2025-02-25T16:33:29.735Z","phase":"Phase 1/2","brief_title":"A Study to Test How Well Different Doses of Obrixtamig (BI 764532) in Combination With Ezabenlimab Are Tolerated by People With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3","source_id_and_acronym":"NCT05879978","lead_sponsor":"Boehringer Ingelheim","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e obrixtamig (BI 764532) • ezabenlimab (BI 754091)"],"overall_status":"Recruiting","enrollment":" Enrollment 43","initiation":"Initiation: 07/28/2023","start_date":" 07/28/2023","primary_txt":" Primary completion: 09/05/2025","primary_completion_date":" 09/05/2025","study_txt":" Completion: 09/05/2025","study_completion_date":" 09/05/2025","last_update_posted":"2025-02-07"},{"id":"dbe9ba45-3c65-4db5-a79b-e7b6343a502a","acronym":"","url":"https://clinicaltrials.gov/study/NCT05916313","created_at":"2023-06-23T13:09:23.183Z","updated_at":"2024-07-02T16:35:00.395Z","phase":"Phase 1","brief_title":"A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3","source_id_and_acronym":"NCT05916313","lead_sponsor":"Boehringer Ingelheim","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e obrixtamig (BI 764532)"],"overall_status":"Recruiting","enrollment":" Enrollment 35","initiation":"Initiation: 12/13/2023","start_date":" 12/13/2023","primary_txt":" Primary completion: 08/17/2026","primary_completion_date":" 08/17/2026","study_txt":" Completion: 08/17/2026","study_completion_date":" 08/17/2026","last_update_posted":"2024-05-29"},{"id":"52a22d82-52f6-4985-b6ec-f15e1a181507","acronym":"","url":"https://clinicaltrials.gov/study/NCT04429087","created_at":"2021-01-18T21:19:55.746Z","updated_at":"2024-07-02T16:35:10.281Z","phase":"Phase 1","brief_title":"A Study to Test Different Doses of BI 764532 in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3","source_id_and_acronym":"NCT04429087","lead_sponsor":"Boehringer Ingelheim","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e obrixtamig (BI 764532)"],"overall_status":"Recruiting","enrollment":" Enrollment 282","initiation":"Initiation: 07/15/2020","start_date":" 07/15/2020","primary_txt":" Primary completion: 09/02/2024","primary_completion_date":" 09/02/2024","study_txt":" Completion: 09/22/2025","study_completion_date":" 09/22/2025","last_update_posted":"2024-04-10"}]