[{"id":"87c14e4e-dad4-4085-ba55-6c5babc89000","acronym":"","url":"https://clinicaltrials.gov/study/NCT03843775","created_at":"2021-01-18T18:58:38.993Z","updated_at":"2024-07-02T16:35:38.031Z","phase":"Phase 1/2","brief_title":"A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers","source_id_and_acronym":"NCT03843775","lead_sponsor":"Memorial Sloan Kettering Cancer Center","biomarkers":" BRAF","pipe":" | ","alterations":" BRAF mutation • BRAF fusion • BRAF K601E • BRAF G469A • BRAF L597Q • BRAF L485W • BRAF T599 • BRAF V600_K601delinsE • BRAF K601 • BRAF L597","tags":["BRAF"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • BRAF fusion • BRAF K601E • BRAF G469A • BRAF L597Q • BRAF L485W • BRAF T599 • BRAF V600_K601delinsE • BRAF K601 • BRAF L597"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Mektovi (binimetinib) • Braftovi (encorafenib)"],"overall_status":"Completed","enrollment":" Enrollment 17","initiation":"Initiation: 02/14/2019","start_date":" 02/14/2019","primary_txt":" Primary completion: 09/02/2023","primary_completion_date":" 09/02/2023","study_txt":" Completion: 09/02/2023","study_completion_date":" 09/02/2023","last_update_posted":"2023-09-06"},{"id":"20b63c84-5fbb-4f76-a357-de7569544623","acronym":"","url":"https://clinicaltrials.gov/study/NCT01922583","created_at":"2021-01-18T08:40:42.278Z","updated_at":"2024-07-02T16:37:08.883Z","phase":"Phase 2","brief_title":"AUY922 in Patient With Stage IV NSCLC","source_id_and_acronym":"NCT01922583","lead_sponsor":"National Taiwan University Hospital","biomarkers":" EGFR • HER-2 • BRAF • ALK • RET • ROS1 • EML4 • KIF5B • SLC34A2","pipe":" | ","alterations":" BRAF V600E • EGFR mutation • BRAF mutation • BRAF V600 • HER-2 mutation • ALK positive • EGFR T790M • RET fusion • EGFR exon 20 insertion • ALK rearrangement • HER-2 exon 20 insertion • ALK fusion • RET mutation • KIF5B-RET fusion • ALK translocation • EGFR exon 20 mutation • BRAF D594G • BRAF G469A • EGFR A767_V769dup • HER-2 YVMA • TFG-ALK fusion • BRAF exon 15 mutation","tags":["EGFR • HER-2 • BRAF • ALK • RET • ROS1 • EML4 • KIF5B • SLC34A2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • EGFR mutation • BRAF mutation • BRAF V600 • HER-2 mutation • ALK positive • EGFR T790M • RET fusion • EGFR exon 20 insertion • ALK rearrangement • HER-2 exon 20 insertion • ALK fusion • RET mutation • KIF5B-RET fusion • ALK translocation • EGFR exon 20 mutation • BRAF D594G • BRAF G469A • EGFR A767_V769dup • HER-2 YVMA • TFG-ALK fusion • BRAF exon 15 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e luminespib (AUY922)"],"overall_status":"Completed","enrollment":" Enrollment 31","initiation":"Initiation: 01/01/2014","start_date":" 01/01/2014","primary_txt":" Primary completion: 02/01/2017","primary_completion_date":" 02/01/2017","study_txt":" Completion: 02/01/2017","study_completion_date":" 02/01/2017","last_update_posted":"2018-07-18"}]