[{"id":"589fc224-1f44-451f-847a-4d0ffa6361d5","acronym":"","url":"https://clinicaltrials.gov/study/NCT02257424","created_at":"2021-01-18T10:36:10.936Z","updated_at":"2024-07-02T16:36:18.245Z","phase":"Phase 1/2","brief_title":"Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma","source_id_and_acronym":"NCT02257424","lead_sponsor":"Abramson Cancer Center of the University of Pennsylvania","biomarkers":" IL2","pipe":" | ","alterations":" BRAF V600E • BRAF V600 • BRAF V600K • BRAF V600R • BRAF V600D • BRAF V600E + BRAF V600K","tags":["IL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • BRAF V600 • BRAF V600K • BRAF V600R • BRAF V600D • BRAF V600E + BRAF V600K"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Mekinist (trametinib) • Tafinlar (dabrafenib) • hydroxychloroquine"],"overall_status":"Completed","enrollment":" Enrollment 50","initiation":"Initiation: 10/01/2014","start_date":" 10/01/2014","primary_txt":" Primary completion: 10/01/2021","primary_completion_date":" 10/01/2021","study_txt":" Completion: 10/01/2021","study_completion_date":" 10/01/2021","last_update_posted":"2022-01-20"},{"id":"1696e2d1-8b90-42d2-9d6f-6add9e0383ae","acronym":"","url":"https://clinicaltrials.gov/study/NCT01804140","created_at":"2021-01-18T07:59:32.939Z","updated_at":"2024-07-02T16:37:27.907Z","phase":"","brief_title":"A Screening Study to Detect BRAF V600 Mutation-Positive Patients For Enrollment Into Clinical Research Studies of Zelboraf (Vemurafenib)","source_id_and_acronym":"NCT01804140","lead_sponsor":"Genentech, Inc.","biomarkers":" BRAF","pipe":" | ","alterations":" BRAF V600E • BRAF V600 • BRAF V600K • BRAF V600R • BRAF V600D","tags":["BRAF"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • BRAF V600 • BRAF V600K • BRAF V600R • BRAF V600D"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Zelboraf (vemurafenib)"],"overall_status":"Completed","enrollment":" Enrollment 662","initiation":"Initiation: 12/01/2012","start_date":" 12/01/2012","primary_txt":" Primary completion: 09/01/2013","primary_completion_date":" 09/01/2013","study_txt":" Completion: 09/01/2013","study_completion_date":" 09/01/2013","last_update_posted":"2016-11-02"}]