[{"id":"762b685b-f9ad-4a92-b22c-56def7ff1101","acronym":"","url":"https://clinicaltrials.gov/study/NCT06331104","created_at":"2024-03-26T14:38:14.768Z","updated_at":"2024-07-02T16:35:11.868Z","phase":"","brief_title":"Network Pharmacology Prediction: Mechanism Study of Puerarin in the Treatment of Giant Cell Tumors of Bone","source_id_and_acronym":"NCT06331104","lead_sponsor":"Changye Zou","biomarkers":" ER","pipe":" | ","alterations":" ER expression • CDKN1B expression","tags":["ER"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER expression • CDKN1B expression"],"overall_status":"Completed","enrollment":" Enrollment 145","initiation":"Initiation: 06/14/2012","start_date":" 06/14/2012","primary_txt":" Primary completion: 08/31/2023","primary_completion_date":" 08/31/2023","study_txt":" Completion: 08/31/2023","study_completion_date":" 08/31/2023","last_update_posted":"2024-04-02"},{"id":"cdf6c9e0-2e9e-4ffb-b0ae-b679fa7d891e","acronym":"","url":"https://clinicaltrials.gov/study/NCT03792256","created_at":"2021-01-18T18:44:58.864Z","updated_at":"2024-07-02T16:36:16.243Z","phase":"Phase 1","brief_title":"Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)","source_id_and_acronym":"NCT03792256","lead_sponsor":"Children's Oncology Group","biomarkers":" RB1 • CD8 • CDK4 • CDK6 • CD4 • CCND3","pipe":" | ","alterations":" RB1 expression • CDK6 expression • CDKN1B expression","tags":["RB1 • CD8 • CDK4 • CDK6 • CD4 • CCND3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e RB1 expression • CDK6 expression • CDKN1B expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ibrance (palbociclib) • cytarabine • doxorubicin hydrochloride • vincristine • prednisone • Oncaspar liquid (pegaspargase) • prednisolone"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 15","initiation":"Initiation: 04/11/2019","start_date":" 04/11/2019","primary_txt":" Primary completion: 06/30/2021","primary_completion_date":" 06/30/2021","study_txt":" Completion: 06/30/2025","study_completion_date":" 06/30/2025","last_update_posted":"2022-03-02"},{"id":"d5c302f6-f239-4bba-903a-aaad67b7c5f1","acronym":"","url":"https://clinicaltrials.gov/study/NCT00129376","created_at":"2021-01-18T00:26:20.714Z","updated_at":"2024-07-02T16:36:58.407Z","phase":"Phase 2","brief_title":"Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Docetaxel as Neoadjuvant Treatment of Breast Cancer Patients","source_id_and_acronym":"NCT00129376","lead_sponsor":"Spanish Breast Cancer Research Group","biomarkers":" BIRC5","pipe":" | ","alterations":" BIRC5 expression • BIRC5 overexpression • CDKN1B expression • TOP2A expression","tags":["BIRC5"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BIRC5 expression • BIRC5 overexpression • CDKN1B expression • TOP2A expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e docetaxel • doxorubicin hydrochloride • cyclophosphamide • cyclophosphamide intravenous"],"overall_status":"Completed","enrollment":" Enrollment 63","initiation":"Initiation: 02/01/2003","start_date":" 02/01/2003","primary_txt":" Primary completion: 07/01/2005","primary_completion_date":" 07/01/2005","study_txt":" Completion: 02/01/2010","study_completion_date":" 02/01/2010","last_update_posted":"2019-07-05"},{"id":"acdd08fa-2d65-43f2-9dc7-c1e5e7171d4e","acronym":"","url":"https://clinicaltrials.gov/study/NCT00068380","created_at":"2021-01-18T00:10:06.283Z","updated_at":"2024-07-02T16:37:09.032Z","phase":"Phase 2","brief_title":"A Phase II Trial of STI571 in the Treatment of Metastatic Gastric Cancer","source_id_and_acronym":"NCT00068380","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" TP53 • BCL2 • CDKN1A","pipe":" | ","alterations":" CDKN1B expression","tags":["TP53 • BCL2 • CDKN1A"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CDKN1B expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e imatinib"],"overall_status":"Completed","enrollment":" Enrollment 17","initiation":"Initiation: 03/01/2004","start_date":" 03/01/2004","primary_txt":" Primary completion: 03/01/2010","primary_completion_date":" 03/01/2010","study_txt":" Completion: 03/01/2010","study_completion_date":" 03/01/2010","last_update_posted":"2018-07-11"}]