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(Rahway, New Jersey USA)","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Tecentriq (atezolizumab) • ifinatamab deruxtecan (DS-7300) • gocatamig (MK-6070)"],"overall_status":"Recruiting","enrollment":" Enrollment 232","initiation":"Initiation: 12/14/2020","start_date":" 12/14/2020","primary_txt":" Primary completion: 06/30/2027","primary_completion_date":" 06/30/2027","study_txt":" Completion: 06/30/2027","study_completion_date":" 06/30/2027","last_update_posted":"2025-02-20"},{"id":"84573df1-6556-4bd1-8122-88ef0fa3cd96","acronym":"","url":"https://clinicaltrials.gov/study/NCT05879978","created_at":"2023-05-30T14:05:15.128Z","updated_at":"2025-02-25T16:33:29.735Z","phase":"Phase 1/2","brief_title":"A Study to Test How Well Different Doses of Obrixtamig (BI 764532) in Combination With Ezabenlimab Are Tolerated by People With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3","source_id_and_acronym":"NCT05879978","lead_sponsor":"Boehringer Ingelheim","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e obrixtamig (BI 764532) • ezabenlimab (BI 754091)"],"overall_status":"Recruiting","enrollment":" Enrollment 43","initiation":"Initiation: 07/28/2023","start_date":" 07/28/2023","primary_txt":" Primary completion: 09/05/2025","primary_completion_date":" 09/05/2025","study_txt":" Completion: 09/05/2025","study_completion_date":" 09/05/2025","last_update_posted":"2025-02-07"},{"id":"cd1de8a7-094e-49cc-8165-4980d260787c","acronym":"SKYBRIDGE","url":"https://clinicaltrials.gov/study/NCT05652686","created_at":"2022-12-15T14:58:20.111Z","updated_at":"2025-02-25T16:27:12.251Z","phase":"Phase 1/2","brief_title":"A Study of Peluntamig (PT217) in Patients with Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)","source_id_and_acronym":"NCT05652686 - 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TRINITY","lead_sponsor":"AbbVie","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Rova-T (rovalpituzumab tesirine)"],"overall_status":"Completed","enrollment":" Enrollment 342","initiation":"Initiation: 01/25/2016","start_date":" 01/25/2016","primary_txt":" Primary completion: 10/19/2018","primary_completion_date":" 10/19/2018","study_txt":" Completion: 10/19/2018","study_completion_date":" 10/19/2018","last_update_posted":"2021-07-30"},{"id":"34ae103a-b412-45f5-90e9-91f1d4a0633e","acronym":"TAHOE","url":"https://clinicaltrials.gov/study/NCT03061812","created_at":"2021-01-18T15:04:51.416Z","updated_at":"2024-07-02T16:36:34.211Z","phase":"Phase 3","brief_title":"Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)","source_id_and_acronym":"NCT03061812 - TAHOE","lead_sponsor":"AbbVie","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e topotecan • Rova-T (rovalpituzumab tesirine)"],"overall_status":"Completed","enrollment":" Enrollment 444","initiation":"Initiation: 04/11/2017","start_date":" 04/11/2017","primary_txt":" Primary completion: 02/12/2020","primary_completion_date":" 02/12/2020","study_txt":" Completion: 02/12/2020","study_completion_date":" 02/12/2020","last_update_posted":"2021-02-23"},{"id":"b30f2f33-84b5-4059-90ef-7847c753b221","acronym":"","url":"https://clinicaltrials.gov/study/NCT03334487","created_at":"2021-01-18T16:27:54.762Z","updated_at":"2024-07-02T16:37:04.374Z","phase":"Phase 3b","brief_title":"Study Evaluating the Safety of Rovalpituzumab Tesirine for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Small Cell Lung Cancer","source_id_and_acronym":"NCT03334487","lead_sponsor":"AbbVie","biomarkers":" DLL3","pipe":" | ","alterations":" DLL3 expression","tags":["DLL3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e DLL3 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Rova-T (rovalpituzumab tesirine)"],"overall_status":"Withdrawn","enrollment":"","initiation":"Initiation: 03/15/2018","start_date":" 03/15/2018","primary_txt":" Primary completion: 12/20/2018","primary_completion_date":" 12/20/2018","study_txt":" Completion: 12/20/2018","study_completion_date":" 12/20/2018","last_update_posted":"2018-12-26"}]