[{"id":"1cf5d688-5325-4132-8563-bf21d97a76a1","acronym":"","url":"https://clinicaltrials.gov/study/NCT06106802","created_at":"2023-10-30T16:12:46.526Z","updated_at":"2024-07-02T16:35:31.209Z","phase":"Phase 2","brief_title":"Lazertinib \u0026 Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment","source_id_and_acronym":"NCT06106802","lead_sponsor":"Samsung Medical Center","biomarkers":" EGFR • BRAF • MET","pipe":" | ","alterations":" EGFR mutation • EGFR L858R • EGFR exon 19 deletion • MET amplification • EGFR C797S • EGFR mutation + MET-CEP7 fusion","tags":["EGFR • BRAF • MET"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • EGFR L858R • EGFR exon 19 deletion • MET amplification • EGFR C797S • EGFR mutation + MET-CEP7 fusion"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Tepmetko (tepotinib) • Lazcluze (lazertinib)"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 47","initiation":"Initiation: 02/02/2024","start_date":" 02/02/2024","primary_txt":" Primary completion: 09/30/2029","primary_completion_date":" 09/30/2029","study_txt":" Completion: 09/30/2029","study_completion_date":" 09/30/2029","last_update_posted":"2023-10-30"},{"id":"464e9e3c-dbca-4658-a0d8-81ceb79ad5f4","acronym":"","url":"https://clinicaltrials.gov/study/NCT05555212","created_at":"2022-09-26T14:56:19.950Z","updated_at":"2024-07-02T16:35:52.081Z","phase":"Phase 1","brief_title":"To Evaluate the Efficacy of QLH11811 in Advanced NSCLC Patients With EGFR Mutation","source_id_and_acronym":"NCT05555212","lead_sponsor":"Qilu Pharmaceutical Co., Ltd.","biomarkers":" EGFR","pipe":" | ","alterations":" EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR C797S","tags":["EGFR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR C797S"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e QLH11811"],"overall_status":"Recruiting","enrollment":" Enrollment 72","initiation":"Initiation: 10/25/2022","start_date":" 10/25/2022","primary_txt":" Primary completion: 12/31/2024","primary_completion_date":" 12/31/2024","study_txt":" Completion: 12/31/2025","study_completion_date":" 12/31/2025","last_update_posted":"2023-03-28"},{"id":"a94c524c-ec96-4f51-b46e-9a20cc2c1fa2","acronym":"","url":"https://clinicaltrials.gov/study/NCT05435248","created_at":"2022-06-28T15:54:09.835Z","updated_at":"2024-07-02T16:36:08.242Z","phase":"Phase 1/2","brief_title":"Hase 1/2 Study of HS-10375 in Patients With Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)","source_id_and_acronym":"NCT05435248","lead_sponsor":"Jiangsu Hansoh Pharmaceutical Co., Ltd.","biomarkers":" EGFR","pipe":" | ","alterations":" EGFR mutation • EGFR C797S","tags":["EGFR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • EGFR C797S"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HS-10375"],"overall_status":"Recruiting","enrollment":" Enrollment 354","initiation":"Initiation: 03/02/2022","start_date":" 03/02/2022","primary_txt":" Primary completion: 03/31/2025","primary_completion_date":" 03/31/2025","study_txt":" Completion: 03/31/2026","study_completion_date":" 03/31/2026","last_update_posted":"2022-06-28"},{"id":"64e67a3e-3f33-43b4-8207-808c11c5daa1","acronym":"","url":"https://clinicaltrials.gov/study/NCT02991274","created_at":"2021-01-18T14:42:49.327Z","updated_at":"2024-07-02T16:36:58.940Z","phase":"","brief_title":"ARTEMIS DIANE T790M (An Amino Acid Substitution at Position 790 in EGFR, From a Threonine (T) to a Methionine (M)) Mutation at Hospital Laboratories in Comparison With Central Laboratory","source_id_and_acronym":"NCT02991274","lead_sponsor":"AstraZeneca","biomarkers":" EGFR","pipe":" | ","alterations":" EGFR mutation • EGFR T790M • EGFR C797S","tags":["EGFR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • EGFR T790M • EGFR C797S"],"overall_status":"Completed","enrollment":" Enrollment 897","initiation":"Initiation: 01/16/2017","start_date":" 01/16/2017","primary_txt":" Primary completion: 06/29/2018","primary_completion_date":" 06/29/2018","study_txt":" Completion: 06/29/2018","study_completion_date":" 06/29/2018","last_update_posted":"2019-06-12"}]