[{"id":"2ca713cd-3802-4667-a3c8-0c37550af8cc","acronym":"HERIZON","url":"https://clinicaltrials.gov/study/NCT02795988","created_at":"2021-01-18T13:43:05.742Z","updated_at":"2024-07-02T16:35:15.239Z","phase":"Phase 1/2","brief_title":"A Study of IMU-131(HER-Vaxx) and Chemotherapy Compared to Chemotherapy Only in Patients With HER2 Positive Advanced Gastric Cancer","source_id_and_acronym":"NCT02795988 - HERIZON","lead_sponsor":"Imugene Limited","biomarkers":" HER-2 • CD8 • CD4","pipe":" | ","alterations":" HER-2 overexpression","tags":["HER-2 • CD8 • CD4"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 overexpression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • 5-fluorouracil • capecitabine • oxaliplatin • Her-VAXX"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 36","initiation":"Initiation: 08/30/2017","start_date":" 08/30/2017","primary_txt":" Primary completion: 03/01/2024","primary_completion_date":" 03/01/2024","study_txt":" Completion: 08/01/2024","study_completion_date":" 08/01/2024","last_update_posted":"2024-03-12"},{"id":"9a88bc4f-4c59-45a6-ae3f-96237c18bc11","acronym":"nextHERIZON","url":"https://clinicaltrials.gov/study/NCT05311176","created_at":"2022-04-05T14:52:54.138Z","updated_at":"2024-07-02T16:35:17.103Z","phase":"Phase 2","brief_title":"A Study of IMU-131 (HER-Vaxx) in Combination With Chemotherapy or Pembrolizumab in Patients With Metastatic HER2/Neu Over-Expressing Gastric Cancer (nextHERIZON)","source_id_and_acronym":"NCT05311176 - nextHERIZON","lead_sponsor":"Imugene Limited","biomarkers":" HER-2 • PD-L1 • IFNG • TNFA • IL2 • IL10","pipe":" | ","alterations":" PD-L1 expression • HER-2 overexpression • HER-2 expression","tags":["HER-2 • PD-L1 • IFNG • TNFA • IL2 • IL10"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PD-L1 expression • HER-2 overexpression • HER-2 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Herceptin (trastuzumab) • paclitaxel • Cyramza (ramucirumab) • irinotecan • Her-VAXX"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 7","initiation":"Initiation: 08/17/2022","start_date":" 08/17/2022","primary_txt":" Primary completion: 03/31/2024","primary_completion_date":" 03/31/2024","study_txt":" Completion: 07/01/2026","study_completion_date":" 07/01/2026","last_update_posted":"2024-02-29"}]