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IL2","pipe":" | ","alterations":" PD-L1 expression","tags":["IL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PD-L1 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Opdivo (nivolumab) • Yervoy (ipilimumab) • lorukafusp alfa (APN301)"],"overall_status":"Suspended","enrollment":" Enrollment 61","initiation":"Initiation: 01/30/2020","start_date":" 01/30/2020","primary_txt":" Primary completion: 08/15/2025","primary_completion_date":" 08/15/2025","study_txt":" Completion: 08/15/2026","study_completion_date":" 08/15/2026","last_update_posted":"2024-09-19"},{"id":"07d4b193-8962-44f1-ada5-2462a5073e52","acronym":"KEYNOTE-A78","url":"https://clinicaltrials.gov/study/NCT03978689","created_at":"2021-01-18T19:34:01.417Z","updated_at":"2025-02-25T16:09:12.255Z","phase":"Phase 1","brief_title":"A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma","source_id_and_acronym":"NCT03978689 - KEYNOTE-A78","lead_sponsor":"Cue 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12/01/2028","study_completion_date":" 12/01/2028","last_update_posted":"2024-06-05"},{"id":"92f8d52f-8230-4bcf-832a-25726a2e7d8a","acronym":"","url":"https://clinicaltrials.gov/study/NCT03190941","created_at":"2021-01-18T15:44:01.911Z","updated_at":"2024-07-02T16:34:38.067Z","phase":"Phase 1/2","brief_title":"Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients","source_id_and_acronym":"NCT03190941","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" KRAS • ALK • NRAS • HRAS","pipe":" | ","alterations":" KRAS mutation • NRAS mutation • KRAS G12V • HRAS mutation • KRAS G12 • NRAS G12 • HLA-A*11 • NRAS G12V","tags":["KRAS • ALK • NRAS • HRAS"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • NRAS mutation • KRAS G12V • HRAS mutation • KRAS G12 • NRAS G12 • HLA-A*11 • NRAS G12V"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cyclophosphamide • fludarabine IV • Proleukin (aldesleukin) • cyclophosphamide intravenous"],"overall_status":"Recruiting","enrollment":" Enrollment 110","initiation":"Initiation: 09/21/2017","start_date":" 09/21/2017","primary_txt":" Primary completion: 06/29/2027","primary_completion_date":" 06/29/2027","study_txt":" Completion: 06/29/2028","study_completion_date":" 06/29/2028","last_update_posted":"2024-06-05"},{"id":"ea2426dc-fd65-4541-b437-a3fa2dace5ba","acronym":"Promise","url":"https://clinicaltrials.gov/study/NCT06081907","created_at":"2023-10-14T01:13:10.291Z","updated_at":"2024-07-02T16:35:00.048Z","phase":"Phase 1/2","brief_title":"The Efficacy and Safety of IBI363 in Solid Tumors","source_id_and_acronym":"NCT06081907 - Promise","lead_sponsor":"Hunan Province Tumor Hospital","biomarkers":" EGFR • HER-2 • PD-L1 • BRAF • ALK • RET • CD73 • NTRK","pipe":" | ","alterations":" BRAF V600E • EGFR mutation • BRAF V600 • RET fusion • ALK fusion • ALK mutation","tags":["EGFR • HER-2 • PD-L1 • BRAF • ALK • RET • CD73 • NTRK"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • EGFR mutation • BRAF V600 • RET fusion • ALK fusion • ALK mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e erlotinib • Lenvima (lenvatinib)"],"overall_status":"Recruiting","enrollment":" Enrollment 430","initiation":"Initiation: 12/25/2023","start_date":" 12/25/2023","primary_txt":" Primary completion: 12/01/2026","primary_completion_date":" 12/01/2026","study_txt":" Completion: 09/01/2028","study_completion_date":" 09/01/2028","last_update_posted":"2024-05-30"},{"id":"9c16748b-c315-47c8-8692-ae028f1c0f22","acronym":"","url":"https://clinicaltrials.gov/study/NCT05194735","created_at":"2022-01-18T12:54:11.846Z","updated_at":"2024-07-02T16:35:00.596Z","phase":"Phase 1/2","brief_title":"Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors","source_id_and_acronym":"NCT05194735","lead_sponsor":"Alaunos Therapeutics","biomarkers":" IFNG • IL6 • TNFA • IL2","pipe":" | ","alterations":" MSI-H/dMMR","tags":["IFNG • IL6 • TNFA • IL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e MSI-H/dMMR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Proleukin (aldesleukin)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 180","initiation":"Initiation: 04/04/2022","start_date":" 04/04/2022","primary_txt":" Primary completion: 11/30/2024","primary_completion_date":" 11/30/2024","study_txt":" Completion: 11/30/2024","study_completion_date":" 11/30/2024","last_update_posted":"2024-05-29"},{"id":"bda79509-21d5-4671-9520-4c738fdfa0e8","acronym":"","url":"https://clinicaltrials.gov/study/NCT02027935","created_at":"2021-05-24T22:52:50.882Z","updated_at":"2024-07-02T16:35:04.435Z","phase":"Phase 2","brief_title":"CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma","source_id_and_acronym":"NCT02027935","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" BRAF • IL2 • MLANA","pipe":" | ","alterations":" BRAF mutation • BRAF V600","tags":["BRAF • IL2 • MLANA"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • BRAF V600"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Yervoy (ipilimumab) • cyclophosphamide • Proleukin (aldesleukin) • cyclophosphamide intravenous"],"overall_status":"Completed","enrollment":" Enrollment 16","initiation":"Initiation: 01/22/2015","start_date":" 01/22/2015","primary_txt":" Primary completion: 04/12/2024","primary_completion_date":" 04/12/2024","study_txt":" Completion: 04/12/2024","study_completion_date":" 04/12/2024","last_update_posted":"2024-05-10"},{"id":"e96ac04f-d494-4797-b71d-2048e4719923","acronym":"","url":"https://clinicaltrials.gov/study/NCT03318900","created_at":"2021-01-18T16:23:25.179Z","updated_at":"2024-07-02T16:35:05.191Z","phase":"Phase 1/2","brief_title":"T-Cell Infusion, Aldesleukin, and Utomilumab in Treating Patients With Recurrent Ovarian 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T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma","source_id_and_acronym":"NCT01955460","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" NGFR • TGFA","pipe":" | ","alterations":" TILs","tags":["NGFR • TGFA"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TILs"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cyclophosphamide • fludarabine IV • Proleukin (aldesleukin) • cyclophosphamide intravenous"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 15","initiation":"Initiation: 10/15/2014","start_date":" 10/15/2014","primary_txt":" Primary completion: 06/01/2024","primary_completion_date":" 06/01/2024","study_txt":" Completion: 06/01/2025","study_completion_date":" 06/01/2025","last_update_posted":"2024-04-19"},{"id":"26ef985f-26c3-4561-a72c-4b31906080ac","acronym":"HAMMER","url":"https://clinicaltrials.gov/study/NCT04009681","created_at":"2021-11-23T17:53:44.333Z","updated_at":"2024-07-02T16:35:11.315Z","phase":"Phase 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06/01/2026","last_update_posted":"2024-04-05"},{"id":"9561390b-a03a-41cf-b8b2-50b5f839c95f","acronym":"","url":"https://clinicaltrials.gov/study/NCT05665062","created_at":"2022-12-27T15:59:01.920Z","updated_at":"2024-07-02T16:35:13.523Z","phase":"Phase 1","brief_title":"Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies","source_id_and_acronym":"NCT05665062","lead_sponsor":"Synthekine","biomarkers":" CD19","pipe":" | ","alterations":" CD19 expression","tags":["CD19"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CD19 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cyclophosphamide • fludarabine IV • STK-009/SYNCAR-001"],"overall_status":"Recruiting","enrollment":" Enrollment 36","initiation":"Initiation: 06/24/2022","start_date":" 06/24/2022","primary_txt":" Primary completion: 06/24/2026","primary_completion_date":" 06/24/2026","study_txt":" Completion: 11/01/2026","study_completion_date":" 11/01/2026","last_update_posted":"2024-03-21"},{"id":"937a6000-045b-4256-9396-e3a8e08cb006","acronym":"TUNINTIL","url":"https://clinicaltrials.gov/study/NCT04217473","created_at":"2021-01-18T20:31:59.350Z","updated_at":"2024-07-02T16:35:15.398Z","phase":"Phase 1","brief_title":"TNFalpha and Interleukin 2 Coding Oncolytic Adenovirus TILT-123 During TIL Treatment of Advanced Melanoma","source_id_and_acronym":"NCT04217473 - TUNINTIL","lead_sponsor":"TILT Biotherapeutics Ltd.","biomarkers":" BRAF • IL2","pipe":" | ","alterations":" TILs","tags":["BRAF • IL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TILs"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e igrelimogene litadenorepvec (TILT-123)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 17","initiation":"Initiation: 02/26/2020","start_date":" 02/26/2020","primary_txt":" Primary completion: 12/12/2023","primary_completion_date":" 12/12/2023","study_txt":" Completion: 12/01/2024","study_completion_date":" 12/01/2024","last_update_posted":"2024-03-11"},{"id":"a435469f-1cf1-4b7f-a476-32a5089846f8","acronym":"PIVOT IO 011","url":"https://clinicaltrials.gov/study/NCT04540705","created_at":"2021-01-18T21:43:33.570Z","updated_at":"2024-07-02T16:35:17.512Z","phase":"Phase 1","brief_title":"A Study to Compare Bempegaldesleukin (BEMPEG: NKTR-214) Combined With Nivolumab and Tyrosine Kinase Inhibitor (TKI) to Nivolumab and TKI Alone in Participants With Previously Untreated Kidney Cancer That is Advanced or Has Spread","source_id_and_acronym":"NCT04540705 - PIVOT IO 011","lead_sponsor":"Bristol-Myers Squibb","biomarkers":" PD-L1","pipe":"","alterations":" ","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • axitinib • bempegaldesleukin (NKTR-214)"],"overall_status":"Completed","enrollment":" Enrollment 30","initiation":"Initiation: 09/11/2020","start_date":" 09/11/2020","primary_txt":" Primary completion: 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