[{"id":"e6c12daa-0172-4ab1-909e-fd452225ee39","acronym":"","url":"https://clinicaltrials.gov/study/NCT05879822","created_at":"2023-05-30T14:05:13.031Z","updated_at":"2025-02-25T16:55:01.117Z","phase":"Phase 2","brief_title":"A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive","source_id_and_acronym":"NCT05879822","lead_sponsor":"Incyte Corporation","biomarkers":" PD-L1 • MSI","pipe":" | ","alterations":" PD-L1 expression • MSI-H/dMMR","tags":["PD-L1 • MSI"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PD-L1 expression • MSI-H/dMMR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e INCB99280"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 73","initiation":"Initiation: 10/30/2023","start_date":" 10/30/2023","primary_txt":" Primary completion: 07/22/2026","primary_completion_date":" 07/22/2026","study_txt":" Completion: 07/22/2026","study_completion_date":" 07/22/2026","last_update_posted":"2025-02-04"},{"id":"67745e72-41f8-4672-aab3-e3a773042f26","acronym":"","url":"https://clinicaltrials.gov/study/NCT06039384","created_at":"2023-09-15T18:10:07.414Z","updated_at":"2025-02-25T14:18:18.295Z","phase":"Phase 1","brief_title":"A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation","source_id_and_acronym":"NCT06039384","lead_sponsor":"Incyte Corporation","biomarkers":" EGFR • KRAS • MSI","pipe":" | ","alterations":" KRAS mutation • MSI-H/dMMR • KRAS G12C • RAS wild-type • KRAS G12","tags":["EGFR • KRAS • MSI"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • MSI-H/dMMR • KRAS G12C • RAS wild-type • KRAS G12"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Krazati (adagrasib) • INCB99280"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 6","initiation":"Initiation: 12/28/2023","start_date":" 12/28/2023","primary_txt":" Primary completion: 11/03/2025","primary_completion_date":" 11/03/2025","study_txt":" Completion: 11/03/2025","study_completion_date":" 11/03/2025","last_update_posted":"2024-11-28"}]