[{"id":"28d28f42-9a11-470f-aad6-b354ed154518","acronym":"PULMO-01","url":"https://clinicaltrials.gov/study/NCT06879717","created_at":"2025-09-07T02:00:11.544Z","updated_at":"2025-09-07T02:00:11.544Z","phase":"Phase 1/2","brief_title":"A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients","source_id_and_acronym":"NCT06879717 - PULMO-01","lead_sponsor":"iOnctura","biomarkers":" IL7R","pipe":"","alterations":" ","tags":["IL7R"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e docetaxel • Jemperli (dostarlimab-gxly) • roginolisib (IOA-244)"],"overall_status":"Recruiting","enrollment":" Enrollment 45","initiation":"Initiation: 04/22/2025","start_date":" 04/22/2025","primary_txt":" Primary completion: 01/01/2027","primary_completion_date":" 01/01/2027","study_txt":" Completion: 01/01/2028","study_completion_date":" 01/01/2028","last_update_posted":"2025-05-13"},{"id":"d058e27d-9b11-457d-b07a-f06069999ed1","acronym":"DIONE-01","url":"https://clinicaltrials.gov/study/NCT04328844","created_at":"2021-01-18T20:57:49.860Z","updated_at":"2024-07-02T16:35:44.430Z","phase":"Phase 1","brief_title":"A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers","source_id_and_acronym":"NCT04328844 - DIONE-01","lead_sponsor":"iOnctura","biomarkers":" PD-L1 • BRAF • ALK • ROS1 • MSLN","pipe":" | ","alterations":" BRAF mutation • BRAF V600 • ALK translocation","tags":["PD-L1 • BRAF • ALK • ROS1 • MSLN"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • BRAF V600 • ALK translocation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • Bavencio (avelumab) • Jakafi (ruxolitinib) • pemetrexed • roginolisib (IOA-244)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 210","initiation":"Initiation: 02/25/2020","start_date":" 02/25/2020","primary_txt":" Primary completion: 09/01/2023","primary_completion_date":" 09/01/2023","study_txt":" Completion: 04/01/2024","study_completion_date":" 04/01/2024","last_update_posted":"2023-06-29"}]