[{"id":"1d571185-66c3-4224-a385-8f3e4c2f1022","acronym":"PATHFINDER","url":"https://clinicaltrials.gov/study/NCT03580655","created_at":"2021-01-18T17:36:58.229Z","updated_at":"2024-07-02T16:35:41.207Z","phase":"Phase 2","brief_title":"(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis","source_id_and_acronym":"NCT03580655 - PATHFINDER","lead_sponsor":"Blueprint Medicines Corporation","biomarkers":" TMB • KIT","pipe":" | ","alterations":" KIT mutation • KIT D816V","tags":["TMB • KIT"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KIT mutation • KIT D816V"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ayvakit (avapritinib)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 103","initiation":"Initiation: 11/21/2018","start_date":" 11/21/2018","primary_txt":" Primary completion: 01/31/2026","primary_completion_date":" 01/31/2026","study_txt":" Completion: 01/31/2026","study_completion_date":" 01/31/2026","last_update_posted":"2023-08-02"},{"id":"0b135f3f-be0a-43ad-bf86-0ed39a7b1f3a","acronym":"EXPLORER","url":"https://clinicaltrials.gov/study/NCT02561988","created_at":"2021-01-18T12:24:19.958Z","updated_at":"2024-07-02T16:35:53.073Z","phase":"Phase 1","brief_title":"(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies","source_id_and_acronym":"NCT02561988 - EXPLORER","lead_sponsor":"Blueprint Medicines Corporation","biomarkers":" KIT","pipe":" | ","alterations":" KIT D816V","tags":["KIT"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KIT D816V"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ayvakit (avapritinib)"],"overall_status":"Completed","enrollment":" Enrollment 86","initiation":"Initiation: 03/10/2016","start_date":" 03/10/2016","primary_txt":" Primary completion: 10/05/2022","primary_completion_date":" 10/05/2022","study_txt":" Completion: 01/19/2023","study_completion_date":" 01/19/2023","last_update_posted":"2023-03-17"}]