[{"id":"6624a35f-cee8-4450-8d7f-b7b9c40ad3a2","acronym":"","url":"https://clinicaltrials.gov/study/NCT01647828","created_at":"2023-02-16T00:00:29.876Z","updated_at":"2024-07-02T16:35:55.487Z","phase":"Phase 1b/2","brief_title":"A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer","source_id_and_acronym":"NCT01647828","lead_sponsor":"OncoMed Pharmaceuticals, Inc.","biomarkers":" NOTCH3","pipe":" | ","alterations":" NOTCH3 expression • NOTCH3 overexpression","tags":["NOTCH3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e NOTCH3 expression • NOTCH3 overexpression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e gemcitabine • albumin-bound paclitaxel • tarextumab (OMP-59R5)"],"overall_status":"Completed","enrollment":" Enrollment 217","initiation":"Initiation: 10/01/2012","start_date":" 10/01/2012","primary_txt":" Primary completion: 04/01/2016","primary_completion_date":" 04/01/2016","study_txt":" Completion: 04/01/2016","study_completion_date":" 04/01/2016","last_update_posted":"2023-02-15"},{"id":"35ab7548-637e-4229-8bfc-9998c89fa4e2","acronym":"","url":"https://clinicaltrials.gov/study/NCT01653470","created_at":"2021-01-18T07:07:38.583Z","updated_at":"2024-07-02T16:36:50.836Z","phase":"Phase 1","brief_title":"Study to Evaluate Safety \u0026 Tolerability of BMS-906024 in Combination With Chemotherapy \u0026 to Define DLTs \u0026 MTD of BMS-906024 in Combination With One of the Following Chemotherapy Regimens; Weekly Paclitaxel, 5FU+Irinotecan or Carboplatin+Paclitaxel in Subjects With Advanced / Metastatic Solid Tumors","source_id_and_acronym":"NCT01653470","lead_sponsor":"Bristol-Myers Squibb","biomarkers":" HES1","pipe":" | ","alterations":" NOTCH mutation","tags":["HES1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e NOTCH mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e carboplatin • paclitaxel • 5-fluorouracil • irinotecan • leucovorin calcium • AL101 • fluorouracil topical"],"overall_status":"Completed","enrollment":" Enrollment 141","initiation":"Initiation: 10/12/2012","start_date":" 10/12/2012","primary_txt":" Primary completion: 05/03/2017","primary_completion_date":" 05/03/2017","study_txt":" Completion: 05/08/2017","study_completion_date":" 05/08/2017","last_update_posted":"2020-01-28"}]