[{"id":"1da77410-a879-4bd0-ac76-26adfb53609a","acronym":"","url":"https://clinicaltrials.gov/study/NCT05989828","created_at":"2023-08-14T14:10:18.266Z","updated_at":"2024-07-02T16:35:01.088Z","phase":"Phase 1","brief_title":"A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer","source_id_and_acronym":"NCT05989828","lead_sponsor":"University of Southern California","biomarkers":" HER-2 • PD-L1 • ER • PGR • CTAG1B","pipe":" | ","alterations":" HER-2 negative • PGR negative","tags":["HER-2 • PD-L1 • ER • PGR • CTAG1B"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 negative • PGR negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cyclophosphamide • fludarabine IV • Proleukin (aldesleukin) • NY-ESO-1 TCR"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 20","initiation":"Initiation: 08/01/2024","start_date":" 08/01/2024","primary_txt":" Primary completion: 08/01/2026","primary_completion_date":" 08/01/2026","study_txt":" Completion: 08/01/2027","study_completion_date":" 08/01/2027","last_update_posted":"2024-05-24"},{"id":"305dcf40-a2b4-49db-9ae3-061b8a400c98","acronym":"","url":"https://clinicaltrials.gov/study/NCT02775292","created_at":"2021-03-26T08:18:04.756Z","updated_at":"2025-02-25T14:36:23.101Z","phase":"Phase 1","brief_title":"Gene-Modified T Cells, Vaccine Therapy, and Nivolumab in Treating Patients With Stage IV or Locally Advanced Solid Tumors Expressing NY-ESO-1","source_id_and_acronym":"NCT02775292","lead_sponsor":"Jonsson Comprehensive Cancer Center","biomarkers":" CTAG1B","pipe":"","alterations":" ","tags":["CTAG1B"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Opdivo (nivolumab) • cyclophosphamide • fludarabine IV • Proleukin (aldesleukin) • NY-ESO-1 TCR • cyclophosphamide intravenous"],"overall_status":"Completed","enrollment":" Enrollment 1","initiation":"Initiation: 01/03/2017","start_date":" 01/03/2017","primary_txt":" Primary completion: 04/08/2019","primary_completion_date":" 04/08/2019","study_txt":" Completion: 04/08/2019","study_completion_date":" 04/08/2019","last_update_posted":"2020-07-24"}]