[{"id":"cb6b89eb-4f9f-4788-a9df-5a300e0272bd","acronym":"","url":"https://clinicaltrials.gov/study/NCT04049825","created_at":"2021-01-18T19:51:38.271Z","updated_at":"2024-07-02T16:35:06.344Z","phase":"Phase 1","brief_title":"A Phase 1 Trial of OPB-111077 in Combination With Bendamustine and Rituximab in Patients With r/r DLBCL","source_id_and_acronym":"NCT04049825","lead_sponsor":"Otsuka Pharmaceutical Co., Ltd.","biomarkers":" CD20","pipe":" | ","alterations":" CD20 positive","tags":["CD20"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CD20 positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Rituxan (rituximab) • bendamustine • OPB-111077"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 36","initiation":"Initiation: 11/22/2019","start_date":" 11/22/2019","primary_txt":" Primary completion: 03/01/2025","primary_completion_date":" 03/01/2025","study_txt":" Completion: 03/01/2025","study_completion_date":" 03/01/2025","last_update_posted":"2024-05-02"},{"id":"11a75896-ed72-4de4-bf64-92a7e752fb1f","acronym":"","url":"https://clinicaltrials.gov/study/NCT03158324","created_at":"2021-01-18T15:34:16.926Z","updated_at":"2024-07-02T16:37:21.037Z","phase":"Phase 2a","brief_title":"Phase IIa Dose-Expansion and Biomarker Study of OPB-111077","source_id_and_acronym":"NCT03158324","lead_sponsor":"National University Hospital, Singapore","biomarkers":" EGFR • BRAF • ALK • EML4 • SIRT1","pipe":" | ","alterations":" EGFR mutation • BRAF mutation • ALK positive • EML4-ALK fusion • ALK fusion • ALK mutation • RET mutation","tags":["EGFR • BRAF • ALK • EML4 • SIRT1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • BRAF mutation • ALK positive • EML4-ALK fusion • ALK fusion • ALK mutation • RET mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e OPB-111077"],"overall_status":"Unknown status","enrollment":" Enrollment 52","initiation":"Initiation: 05/22/2017","start_date":" 05/22/2017","primary_txt":" Primary completion: 05/22/2020","primary_completion_date":" 05/22/2020","study_txt":" Completion: 11/30/2020","study_completion_date":" 11/30/2020","last_update_posted":"2017-06-15"}]