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LEAP-007","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" PD-L1","pipe":" | ","alterations":" PD-L1 expression","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PD-L1 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Completed","enrollment":" Enrollment 623","initiation":"Initiation: 03/13/2019","start_date":" 03/13/2019","primary_txt":" Primary completion: 05/19/2021","primary_completion_date":" 05/19/2021","study_txt":" Completion: 04/24/2024","study_completion_date":" 04/24/2024","last_update_posted":"2025-02-14"},{"id":"231092fb-00ef-4553-bd1a-e401bd09459d","acronym":"LITESPARK-016","url":"https://clinicaltrials.gov/study/NCT04976634","created_at":"2021-07-26T17:53:23.648Z","updated_at":"2025-02-25T15:19:12.763Z","phase":"Phase 2","brief_title":"Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)","source_id_and_acronym":"NCT04976634 - LITESPARK-016","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" MSI","pipe":"","alterations":" ","tags":["MSI"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib) • Welireg (belzutifan)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 730","initiation":"Initiation: 08/18/2021","start_date":" 08/18/2021","primary_txt":" Primary completion: 03/22/2027","primary_completion_date":" 03/22/2027","study_txt":" Completion: 03/22/2027","study_completion_date":" 03/22/2027","last_update_posted":"2025-02-12"},{"id":"a46eecea-cdfb-4325-ac71-c96ea8e37386","acronym":"","url":"https://clinicaltrials.gov/study/NCT05823311","created_at":"2023-04-21T15:04:25.336Z","updated_at":"2025-02-25T15:20:26.716Z","phase":"Phase 3","brief_title":"Lenvatinib, Tislelizumab Combined with Gemcitabine and Cisplatin (GPLET) in the Treatment of Advanced Cholangiocarcinoma","source_id_and_acronym":"NCT05823311","lead_sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","biomarkers":" PD-L1","pipe":"","alterations":" ","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • gemcitabine • Lenvima (lenvatinib) • Tevimbra (tislelizumab-jsgr)"],"overall_status":"Recruiting","enrollment":" Enrollment 80","initiation":"Initiation: 09/01/2023","start_date":" 09/01/2023","primary_txt":" Primary completion: 12/31/2026","primary_completion_date":" 12/31/2026","study_txt":" Completion: 12/31/2027","study_completion_date":" 12/31/2027","last_update_posted":"2025-02-10"},{"id":"f87d079d-5408-46e1-abc8-978710f92fcc","acronym":"","url":"https://clinicaltrials.gov/study/NCT05532059","created_at":"2022-09-08T13:55:00.765Z","updated_at":"2025-02-25T15:27:37.097Z","phase":"Phase 2","brief_title":"Lenvatinib, Tislelizumab Plus Gemcitabine and Cisplatin (GPLET) in Patients with Advanced Cholangiocarcinoma","source_id_and_acronym":"NCT05532059","lead_sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","biomarkers":" PD-L1","pipe":"","alterations":" ","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • gemcitabine • Lenvima (lenvatinib) • Tevimbra (tislelizumab-jsgr)"],"overall_status":"Recruiting","enrollment":" Enrollment 100","initiation":"Initiation: 01/31/2022","start_date":" 01/31/2022","primary_txt":" Primary completion: 08/31/2025","primary_completion_date":" 08/31/2025","study_txt":" Completion: 08/31/2028","study_completion_date":" 08/31/2028","last_update_posted":"2025-02-10"},{"id":"f5cb8c43-6865-4b75-b3de-bf63f4e8a4e4","acronym":"LEAP-015","url":"https://clinicaltrials.gov/study/NCT04662710","created_at":"2021-01-19T20:42:39.419Z","updated_at":"2025-02-25T13:35:41.688Z","phase":"Phase 3","brief_title":"Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)","source_id_and_acronym":"NCT04662710 - 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PELICAN","lead_sponsor":"Imperial College London","biomarkers":" PD-1 • VEGFA • CD34 • FOXP3","pipe":"","alterations":" ","tags":["PD-1 • VEGFA • CD34 • FOXP3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • carboplatin • Lenvima (lenvatinib) • etoposide IV"],"overall_status":"Recruiting","enrollment":" Enrollment 20","initiation":"Initiation: 07/08/2024","start_date":" 07/08/2024","primary_txt":" Primary completion: 03/02/2028","primary_completion_date":" 03/02/2028","study_txt":" Completion: 08/02/2028","study_completion_date":" 08/02/2028","last_update_posted":"2025-01-30"},{"id":"d09ef236-9ffc-468c-9ac9-80033eba5a47","acronym":"","url":"https://clinicaltrials.gov/study/NCT05147558","created_at":"2021-12-07T13:53:36.843Z","updated_at":"2025-02-25T16:17:01.717Z","phase":"Phase 2","brief_title":"A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma","source_id_and_acronym":"NCT05147558","lead_sponsor":"Memorial Sloan Kettering Cancer Center","biomarkers":" MSI","pipe":" | ","alterations":" MSI-H/dMMR","tags":["MSI"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e MSI-H/dMMR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Recruiting","enrollment":" Enrollment 40","initiation":"Initiation: 12/23/2021","start_date":" 12/23/2021","primary_txt":" Primary completion: 12/23/2025","primary_completion_date":" 12/23/2025","study_txt":" Completion: 12/23/2025","study_completion_date":" 12/23/2025","last_update_posted":"2025-01-27"},{"id":"6d8ce925-047e-4380-9392-20b7805d056d","acronym":"","url":"https://clinicaltrials.gov/study/NCT04955743","created_at":"2021-07-09T12:57:14.611Z","updated_at":"2025-02-25T16:16:25.608Z","phase":"Phase 2","brief_title":"Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma","source_id_and_acronym":"NCT04955743","lead_sponsor":"Yale University","biomarkers":" BRAF","pipe":" | ","alterations":" BRAF mutation","tags":["BRAF"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Recruiting","enrollment":" Enrollment 56","initiation":"Initiation: 02/09/2022","start_date":" 02/09/2022","primary_txt":" Primary completion: 01/31/2027","primary_completion_date":" 01/31/2027","study_txt":" Completion: 01/31/2027","study_completion_date":" 01/31/2027","last_update_posted":"2024-12-24"},{"id":"05e655b5-ceb5-4cfa-ba00-4d49783fd7fb","acronym":"LEAP-003","url":"https://clinicaltrials.gov/study/NCT03820986","created_at":"2021-01-18T18:52:34.602Z","updated_at":"2025-02-25T13:35:12.099Z","phase":"Phase 3","brief_title":"Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)","source_id_and_acronym":"NCT03820986 - LEAP-003","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" BRAF","pipe":" | ","alterations":" BRAF mutation • BRAF V600 • BRAF wild-type","tags":["BRAF"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • BRAF V600 • BRAF wild-type"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Completed","enrollment":" Enrollment 674","initiation":"Initiation: 03/12/2019","start_date":" 03/12/2019","primary_txt":" Primary completion: 01/18/2023","primary_completion_date":" 01/18/2023","study_txt":" Completion: 11/01/2024","study_completion_date":" 11/01/2024","last_update_posted":"2024-12-02"},{"id":"619fd7c9-dbb3-4095-b877-184ef406df55","acronym":"LEAP-003 China Extension","url":"https://clinicaltrials.gov/study/NCT04889118","created_at":"2021-05-17T18:56:08.830Z","updated_at":"2025-02-25T13:35:49.940Z","phase":"Phase 3","brief_title":"Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study","source_id_and_acronym":"NCT04889118 - LEAP-003 China Extension","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" BRAF","pipe":" | ","alterations":" BRAF mutation • BRAF V600 • BRAF wild-type","tags":["BRAF"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • BRAF V600 • BRAF wild-type"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Completed","enrollment":" Enrollment 131","initiation":"Initiation: 07/14/2020","start_date":" 07/14/2020","primary_txt":" Primary completion: 01/18/2023","primary_completion_date":" 01/18/2023","study_txt":" Completion: 11/01/2024","study_completion_date":" 11/01/2024","last_update_posted":"2024-12-02"},{"id":"6e09028c-351c-49a3-ae4b-ecc4e168b4c6","acronym":"","url":"https://clinicaltrials.gov/study/NCT04267120","created_at":"2021-01-18T20:44:00.448Z","updated_at":"2025-02-25T16:10:00.555Z","phase":"Phase 2","brief_title":"Lenvatinib (LEN) in Combination With Pembrolizumab (KEYtruda) in Subjects With Locally Advanced or Metastatic Non-clear Cell Renal Cell Carcinoma (The LENKYN Trial)","source_id_and_acronym":"NCT04267120","lead_sponsor":"Washington University School of Medicine","biomarkers":" SDHB • TSC1","pipe":" | ","alterations":" TSC1 deletion","tags":["SDHB • TSC1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TSC1 deletion"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 11","initiation":"Initiation: 07/29/2020","start_date":" 07/29/2020","primary_txt":" Primary completion: 07/09/2024","primary_completion_date":" 07/09/2024","study_txt":" Completion: 12/31/2025","study_completion_date":" 12/31/2025","last_update_posted":"2024-11-26"},{"id":"26ce8992-3a8f-449a-80fd-e840f4035ed9","acronym":"AMBER","url":"https://clinicaltrials.gov/study/NCT06068153","created_at":"2023-10-05T16:11:10.857Z","updated_at":"2025-02-25T13:36:28.930Z","phase":"Phase 2","brief_title":"AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC","source_id_and_acronym":"NCT06068153 - AMBER","lead_sponsor":"ETOP IBCSG Partners Foundation","biomarkers":" KRAS","pipe":" | ","alterations":" KRAS mutation • KRAS G12C • KRAS G12","tags":["KRAS"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • KRAS G12C • KRAS G12"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Lenvima (lenvatinib) • Lumakras (sotorasib)"],"overall_status":"Withdrawn","enrollment":"","initiation":"Initiation: 03/01/2025","start_date":" 03/01/2025","primary_txt":" Primary completion: 09/30/2026","primary_completion_date":" 09/30/2026","study_txt":" Completion: 12/30/2026","study_completion_date":" 12/30/2026","last_update_posted":"2024-11-20"},{"id":"17df3b54-8527-4d38-a58f-5e18bf2e1770","acronym":"","url":"https://clinicaltrials.gov/study/NCT06110793","created_at":"2023-11-01T15:12:25.826Z","updated_at":"2025-02-25T16:19:14.320Z","phase":"Phase 1/2","brief_title":"A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast Cancer","source_id_and_acronym":"NCT06110793","lead_sponsor":"Memorial Sloan Kettering Cancer Center","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 negative","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib) • fulvestrant"],"overall_status":"Recruiting","enrollment":" Enrollment 43","initiation":"Initiation: 12/29/2023","start_date":" 12/29/2023","primary_txt":" Primary completion: 11/01/2026","primary_completion_date":" 11/01/2026","study_txt":" Completion: 11/01/2026","study_completion_date":" 11/01/2026","last_update_posted":"2024-11-18"},{"id":"9ef28cb0-6b0e-4242-8ea3-6de25a48faed","acronym":"LEAP-008","url":"https://clinicaltrials.gov/study/NCT03976375","created_at":"2021-01-18T19:33:26.274Z","updated_at":"2025-02-25T13:35:24.264Z","phase":"Phase 3","brief_title":"Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)","source_id_and_acronym":"NCT03976375 - LEAP-008","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" EGFR • KRAS • ALK • ROS1","pipe":" | ","alterations":" KRAS mutation • EGFR L858R • ALK rearrangement • RAS mutation","tags":["EGFR • KRAS • ALK • ROS1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • EGFR L858R • ALK rearrangement • RAS mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • docetaxel • Lenvima (lenvatinib)"],"overall_status":"Completed","enrollment":" Enrollment 422","initiation":"Initiation: 06/26/2019","start_date":" 06/26/2019","primary_txt":" Primary completion: 08/11/2023","primary_completion_date":" 08/11/2023","study_txt":" Completion: 08/22/2024","study_completion_date":" 08/22/2024","last_update_posted":"2024-11-18"},{"id":"a4ed02c4-6f06-4ed4-a5b9-d63c7176c2eb","acronym":"LEAP-005","url":"https://clinicaltrials.gov/study/NCT03797326","created_at":"2021-01-17T17:13:36.138Z","updated_at":"2025-02-25T13:35:11.465Z","phase":"Phase 2","brief_title":"Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)","source_id_and_acronym":"NCT03797326 - LEAP-005","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" HER-2 • PD-L1 • ER • PGR","pipe":"","alterations":" ","tags":["HER-2 • PD-L1 • ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Completed","enrollment":" Enrollment 603","initiation":"Initiation: 02/12/2019","start_date":" 02/12/2019","primary_txt":" Primary completion: 10/28/2024","primary_completion_date":" 10/28/2024","study_txt":" Completion: 10/28/2024","study_completion_date":" 10/28/2024","last_update_posted":"2024-11-15"},{"id":"7ce398ac-e594-403c-828e-b3f6d6572732","acronym":"PEMMELA","url":"https://clinicaltrials.gov/study/NCT04287829","created_at":"2021-01-18T20:48:44.381Z","updated_at":"2025-02-25T16:10:03.930Z","phase":"Phase 2","brief_title":"Pembrolizumab Plus Lenvatinib In Second Line and Third Line Malignant Pleural mesotheLioma Patients","source_id_and_acronym":"NCT04287829 - PEMMELA","lead_sponsor":"The Netherlands Cancer Institute","biomarkers":" TMB • CTLA4","pipe":"","alterations":" ","tags":["TMB • CTLA4"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • cisplatin • Lenvima (lenvatinib)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 58","initiation":"Initiation: 03/01/2021","start_date":" 03/01/2021","primary_txt":" Primary completion: 12/05/2024","primary_completion_date":" 12/05/2024","study_txt":" Completion: 03/05/2026","study_completion_date":" 03/05/2026","last_update_posted":"2024-11-05"},{"id":"76a5691d-3c36-403e-ae0a-2107bdb5f547","acronym":"LEAP-017","url":"https://clinicaltrials.gov/study/NCT04776148","created_at":"2021-03-01T13:52:36.340Z","updated_at":"2025-02-25T13:35:46.773Z","phase":"Phase 3","brief_title":"Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)","source_id_and_acronym":"NCT04776148 - LEAP-017","lead_sponsor":"Merck Sharp \u0026 Dohme LLC","biomarkers":" EGFR • KRAS • BRAF • MSI","pipe":" | ","alterations":" BRAF V600E • MSI-H/dMMR • BRAF V600 • KRAS wild-type • RAS wild-type • NRAS wild-type","tags":["EGFR • KRAS • BRAF • MSI"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF V600E • MSI-H/dMMR • BRAF V600 • KRAS wild-type • RAS wild-type • NRAS wild-type"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib) • Stivarga (regorafenib) • Lonsurf (trifluridine/tipiracil)"],"overall_status":"Completed","enrollment":" Enrollment 480","initiation":"Initiation: 03/29/2021","start_date":" 03/29/2021","primary_txt":" Primary completion: 02/20/2023","primary_completion_date":" 02/20/2023","study_txt":" Completion: 09/27/2024","study_completion_date":" 09/27/2024","last_update_posted":"2024-10-29"},{"id":"cefe1ebc-14bd-4e5a-993f-9881a3637cc5","acronym":"LEAP-006 China Extension","url":"https://clinicaltrials.gov/study/NCT04716933","created_at":"2021-01-24T15:53:01.390Z","updated_at":"2025-02-25T13:35:44.968Z","phase":"Phase 3","brief_title":"Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)-China Extension Study","source_id_and_acronym":"NCT04716933 - 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PLANE-PC","lead_sponsor":"University of Michigan Rogel Cancer Center","biomarkers":" SYP • CHGA","pipe":"","alterations":" ","tags":["SYP • CHGA"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Recruiting","enrollment":" Enrollment 50","initiation":"Initiation: 05/25/2021","start_date":" 05/25/2021","primary_txt":" Primary completion: 12/01/2024","primary_completion_date":" 12/01/2024","study_txt":" Completion: 12/01/2024","study_completion_date":" 12/01/2024","last_update_posted":"2024-08-14"},{"id":"a2435d86-98de-4112-83d0-5bc0d0144cd7","acronym":"PECATI","url":"https://clinicaltrials.gov/study/NCT04710628","created_at":"2021-01-19T20:52:22.443Z","updated_at":"2025-02-25T16:11:03.589Z","phase":"Phase 2","brief_title":"Combination of Pembrolizumab and Lenvatinib, in Pre-treated Thymic CArcinoma paTIents","source_id_and_acronym":"NCT04710628 - PECATI","lead_sponsor":"MedSIR","biomarkers":" PD-L1","pipe":" | ","alterations":" PD-L1 expression","tags":["PD-L1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PD-L1 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Lenvima (lenvatinib)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 43","initiation":"Initiation: 09/21/2021","start_date":" 09/21/2021","primary_txt":" Primary completion: 07/01/2024","primary_completion_date":" 07/01/2024","study_txt":" Completion: 01/31/2026","study_completion_date":" 01/31/2026","last_update_posted":"2024-08-08"}]