[{"id":"c74875d8-9130-49eb-b214-6853f919bb75","acronym":"PALATINUS","url":"https://clinicaltrials.gov/study/NCT02499120","created_at":"2021-01-18T12:03:10.689Z","updated_at":"2024-07-02T16:35:37.685Z","phase":"Phase 2","brief_title":"Safety And Efficacy Study Of Palbociclib Plus Cetuximab Versus Cetuximab To Treat Head And Neck Cancer","source_id_and_acronym":"NCT02499120 - PALATINUS","lead_sponsor":"Pfizer","biomarkers":" RB1","pipe":" | ","alterations":" CDKN2A negative • RB1 positive","tags":["RB1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CDKN2A negative • RB1 positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Erbitux (cetuximab) • Ibrance (palbociclib)"],"overall_status":"Completed","enrollment":" Enrollment 125","initiation":"Initiation: 09/10/2015","start_date":" 09/10/2015","primary_txt":" Primary completion: 07/19/2018","primary_completion_date":" 07/19/2018","study_txt":" Completion: 09/07/2022","study_completion_date":" 09/07/2022","last_update_posted":"2023-09-08"},{"id":"4ccc2c43-cf80-4471-8f20-ea4d38f5f9ef","acronym":"","url":"https://clinicaltrials.gov/study/NCT01037790","created_at":"2021-01-18T04:04:21.968Z","updated_at":"2024-07-02T16:36:33.413Z","phase":"Phase 2","brief_title":"Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer","source_id_and_acronym":"NCT01037790","lead_sponsor":"Abramson Cancer Center of the University of Pennsylvania","biomarkers":" HER-2 • KRAS • BRAF • ER • RB1 • CCND1 • CDK4 • CCND2","pipe":" | ","alterations":" KRAS mutation • ER positive • BRAF mutation • CCND1 amplification • CDK4 amplification • RB1 positive • CDK4 mutation","tags":["HER-2 • KRAS • BRAF • ER • RB1 • CCND1 • CDK4 • CCND2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • ER positive • BRAF mutation • CCND1 amplification • CDK4 amplification • RB1 positive • CDK4 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • Ibrance (palbociclib)"],"overall_status":"Completed","enrollment":" Enrollment 304","initiation":"Initiation: 10/01/2009","start_date":" 10/01/2009","primary_txt":" Primary completion: 10/01/2019","primary_completion_date":" 10/01/2019","study_txt":" Completion: 10/01/2019","study_completion_date":" 10/01/2019","last_update_posted":"2021-03-11"}]