[{"id":"db9772f8-853e-4276-a288-f8213fb1a0f0","acronym":"PORCUPINE","url":"https://clinicaltrials.gov/study/NCT04907539","created_at":"2021-05-28T13:52:49.332Z","updated_at":"2024-07-02T16:35:06.261Z","phase":"Phase 2","brief_title":"A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)","source_id_and_acronym":"NCT04907539 - PORCUPINE","lead_sponsor":"Redx Pharma Plc","biomarkers":" RNF43 • RSPO2","pipe":"","alterations":" ","tags":["RNF43 • RSPO2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Opdivo (nivolumab) • Prolia (denosumab) • zamaporvint (RXC004)"],"overall_status":"Completed","enrollment":" Enrollment 25","initiation":"Initiation: 11/08/2021","start_date":" 11/08/2021","primary_txt":" Primary completion: 04/02/2024","primary_completion_date":" 04/02/2024","study_txt":" Completion: 04/02/2024","study_completion_date":" 04/02/2024","last_update_posted":"2024-05-03"},{"id":"f206d692-a2fb-4635-9598-ebcf6ea572de","acronym":"KEYNOTE-E86","url":"https://clinicaltrials.gov/study/NCT04907851","created_at":"2021-06-01T18:53:39.917Z","updated_at":"2025-02-25T16:16:17.834Z","phase":"Phase 2","brief_title":"A Study to Assess RXC004 Efficacy in Advanced Solid Tumours After Progression on Standard of Care (SoC) Therapy (PORCUPINE2)","source_id_and_acronym":"NCT04907851 - KEYNOTE-E86","lead_sponsor":"Redx Pharma Plc","biomarkers":" RNF43","pipe":" | ","alterations":" RNF43 mutation","tags":["RNF43"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e RNF43 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • Prolia (denosumab) • zamaporvint (RXC004)"],"overall_status":"Completed","enrollment":" Enrollment 45","initiation":"Initiation: 12/10/2021","start_date":" 12/10/2021","primary_txt":" Primary completion: 11/30/2023","primary_completion_date":" 11/30/2023","study_txt":" Completion: 11/30/2023","study_completion_date":" 11/30/2023","last_update_posted":"2024-03-08"}]