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class=\"violet\"\u003e|\u003c/b\u003e gemcitabine • adavosertib (AZD1775)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 124","initiation":"Initiation: 07/21/2014","start_date":" 07/21/2014","primary_txt":" Primary completion: 02/03/2022","primary_completion_date":" 02/03/2022","study_txt":" Completion: 02/20/2025","study_completion_date":" 02/20/2025","last_update_posted":"2024-06-07"},{"id":"c7ba05df-48e5-4170-b8f3-f78ce52e05e0","acronym":"","url":"https://clinicaltrials.gov/study/NCT05682170","created_at":"2023-01-12T15:02:24.531Z","updated_at":"2024-07-02T16:35:04.517Z","phase":"Phase 1/2","brief_title":"Study of the ZN-d5 and ZN-c3 in Subjects With Acute Myeloid Leukemia (AML)","source_id_and_acronym":"NCT05682170","lead_sponsor":"K-Group Alpha, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc.","biomarkers":" BCL2","pipe":"","alterations":" ","tags":["BCL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e azenosertib (ZN-c3) • asaretoclax 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recruiting","enrollment":" Enrollment 60","initiation":"Initiation: 01/29/2019","start_date":" 01/29/2019","primary_txt":" Primary completion: 08/30/2024","primary_completion_date":" 08/30/2024","study_txt":" Completion: 08/30/2024","study_completion_date":" 08/30/2024","last_update_posted":"2024-03-22"},{"id":"46c4dafa-648c-4f9b-8154-30165bb2495f","acronym":"","url":"https://clinicaltrials.gov/study/NCT01849146","created_at":"2024-03-06T15:37:16.511Z","updated_at":"2024-07-02T16:35:16.074Z","phase":"Phase 1","brief_title":"Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma","source_id_and_acronym":"NCT01849146","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" TP53 • MGMT • CASP3 • WEE1","pipe":" | ","alterations":" TP53 mutation","tags":["TP53 • MGMT • CASP3 • WEE1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TP53 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e temozolomide • adavosertib 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Solid Tumours","source_id_and_acronym":"NCT02482311","lead_sponsor":"AstraZeneca","biomarkers":" BRCA1 • BRCA2 • BRCA","pipe":" | ","alterations":" BRCA2 mutation • BRCA1 mutation • BRCA wild-type","tags":["BRCA1 • BRCA2 • BRCA"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRCA2 mutation • BRCA1 mutation • BRCA wild-type"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e adavosertib (AZD1775)"],"overall_status":"Completed","enrollment":" Enrollment 92","initiation":"Initiation: 07/01/2015","start_date":" 07/01/2015","primary_txt":" Primary completion: 01/25/2018","primary_completion_date":" 01/25/2018","study_txt":" Completion: 08/22/2019","study_completion_date":" 08/22/2019","last_update_posted":"2023-07-03"},{"id":"d3dd1e14-36e0-44ed-b491-b9afe3ad5f5d","acronym":"","url":"https://clinicaltrials.gov/study/NCT05198804","created_at":"2022-01-20T15:53:52.222Z","updated_at":"2024-07-02T16:35:45.369Z","phase":"Phase 1/2","brief_title":"A Study of ZN-c3 and Niraparib in Subjects With 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