[{"id":"627558e9-c3d7-4f51-90e5-5a44fbbddb52","acronym":"","url":"https://clinicaltrials.gov/study/NCT01351103","created_at":"2021-01-18T05:31:16.537Z","updated_at":"2024-07-02T16:34:59.934Z","phase":"Phase 1","brief_title":"A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands","source_id_and_acronym":"NCT01351103","lead_sponsor":"Novartis Pharmaceuticals","biomarkers":" BRAF • RNF43","pipe":" | ","alterations":" BRAF mutation • RNF43 mutation","tags":["BRAF • RNF43"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BRAF mutation • RNF43 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e spartalizumab (PDR001) • WNT974"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 185","initiation":"Initiation: 12/01/2011","start_date":" 12/01/2011","primary_txt":" Primary completion: 06/14/2021","primary_completion_date":" 06/14/2021","study_txt":" Completion: 06/18/2024","study_completion_date":" 06/18/2024","last_update_posted":"2024-05-30"},{"id":"0f58a0ca-0ebd-407c-a07e-347f60642792","acronym":"","url":"https://clinicaltrials.gov/study/NCT02278133","created_at":"2021-01-18T10:43:25.747Z","updated_at":"2024-07-02T16:37:17.241Z","phase":"Phase 1/2","brief_title":"Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway Mutations","source_id_and_acronym":"NCT02278133","lead_sponsor":"Array BioPharma","biomarkers":" KRAS • RNF43","pipe":" | ","alterations":" KRAS mutation • BRAF V600 • KRAS wild-type • RAS wild-type • RNF43 mutation","tags":["KRAS • RNF43"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e KRAS mutation • BRAF V600 • KRAS wild-type • RAS wild-type • RNF43 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Erbitux (cetuximab) • Braftovi (encorafenib) • WNT974"],"overall_status":"Completed","enrollment":" Enrollment 20","initiation":"Initiation: 12/01/2014","start_date":" 12/01/2014","primary_txt":" Primary completion: 05/31/2016","primary_completion_date":" 05/31/2016","study_txt":" Completion: 06/23/2017","study_completion_date":" 06/23/2017","last_update_posted":"2017-10-09"}]