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AiRuiLi (adebrelimab)
i
Other names: SHR1316, SHR-1316, SHR 1316, HTI-1088, HTI-1316, HTI1088, HTI 1088, HTI 1316, HTI1316
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Company:
Jiangsu Hengrui Pharma
Drug class:
PD-L1 inhibitor
Related drugs:
1d
ACADEMY: A Trial of Apatinib and Adebrelimab in Combination With Chemotherapy in Patients With Unresectable ICC (clinicaltrials.gov)
P2, N=38, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Trial completion date: Oct 2027 --> Oct 2028 | Trial primary completion date: Jun 2026 --> Jun 2027
Trial completion date • Trial primary completion date
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AiTan (rivoceranib) • AiRuiLi (adebrelimab)
8d
ABC-R: Study of Radiotherapy Combined With Platinum, Adebrelimab and Bevazumab in the Treatment of TNBC-BM. (clinicaltrials.gov)
P2, N=58, Recruiting, Fudan University
New P2 trial
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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HER-2 negative • ER negative • HER-2 negative + HR negative
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Avastin (bevacizumab) • cisplatin • carboplatin • AiRuiLi (adebrelimab)
8d
Evaluating the Efficacy and Safety of PD-L1 Monoclonal Antibody Combined With VEX Metronomic Chemotherapy and Concurrent or Delayed Radiotherapy in Patients With Advanced HER2-Negative Breast Cancer With Brain Metastasis (clinicaltrials.gov)
P2, N=102, Recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Not yet recruiting --> Recruiting
Enrollment open
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 negative
|
capecitabine • cyclophosphamide • AiRuiLi (adebrelimab) • Navelbine oral (vinorelbine tartrate oral)
9d
NEOCRTEC2501: Adebrelimab Combined With Neoadjuvant Chemotherapy in Borderline Resectable Locally Advanced Esophageal Squamous Cell Carcinoma (clinicaltrials.gov)
P2, N=42, Recruiting, Sun Yat-sen University
New P2 trial
|
carboplatin • albumin-bound paclitaxel • AiRuiLi (adebrelimab)
9d
Evaluate the Efficacy and Safety of Adebrelimab Combined With Chemotherapy With or Without Radiotherapy as Neoadjuvant Treatment for HER2-Negative Locally Advanced Breast Cancer (clinicaltrials.gov)
P2, N=170, Recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Not yet recruiting --> Recruiting
Enrollment open
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 negative
|
albumin-bound paclitaxel • cyclophosphamide • epirubicin • AiRuiLi (adebrelimab)
14d
SYSKY-2023-1262-02: Combination Immunotherapy of Adebrelimab With Apatinib and Tegafur, Gimeracil and Oteracil Potassium Capsules for Immune Rechallenge Therapy in Esophageal Squamous Cell Carcinoma (clinicaltrials.gov)
P2, N=32, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Trial completion date: Sep 2026 --> Sep 2028 | Trial primary completion date: Mar 2026 --> Mar 2028
Trial completion date • Trial primary completion date
|
AiTan (rivoceranib) • Teysuno (gimeracil/oteracil/tegafur) • AiRuiLi (adebrelimab)
15d
Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial (clinicaltrials.gov)
P2, N=84, Not yet recruiting, Sun Yat-sen University
New P2 trial • pMMR
|
5-fluorouracil • capecitabine • oxaliplatin • irinotecan • leucovorin calcium • Onivyde (nanoliposomal irinotecan) • AiRuiLi (adebrelimab)
16d
Trastuzumab Rezetecan and Adebrelimab as Neoadjuvant Therapy for HER2-Positive Muscle-Invasive Bladder Cancer (clinicaltrials.gov)
P2, N=58, Not yet recruiting, Harbin Medical University
New P2 trial
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 expression
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Herceptin (trastuzumab) • trastuzumab rezetecan (SHR-A1811) • AiRuiLi (adebrelimab)
20d
Adebrelimab Combined With SHR2554 in Relapsed/Refractory PTCL and NK/T-Cell Lymphoma (clinicaltrials.gov)
P1/2, N=40, Not yet recruiting, Sun Yat-sen University
New P1/2 trial
|
zeprumetostat (SHR-2554) • AiRuiLi (adebrelimab)
20d
SHR-8068 in Combination With Adebrelimab, Bevacizumab, and Platinum-Based Chemotherapy as First-line Treatment in Patients With Advanced Biliary Tract Cancer (clinicaltrials.gov)
P2, N=93, Active, not recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Recruiting --> Active, not recruiting
Enrollment closed
|
Avastin (bevacizumab) • cisplatin • gemcitabine • CS1002 (ipilimumab biosimilar) • AiRuiLi (adebrelimab)
21d
OBU-HCC-II-001: Evaluation of Effectiveness and Safety of HAIC in Combination With Adebrelimab and Bevacizumab for Potentially Resectable Hepatocellular Carcinoma (clinicaltrials.gov)
P2, N=40, Suspended, Tianjin Medical University Cancer Institute and Hospital | Trial completion date: Aug 2027 --> Aug 2028 | Recruiting --> Suspended | Trial primary completion date: May 2025 --> May 2027
Trial completion date • Trial suspension • Trial primary completion date
|
Avastin (bevacizumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium • AiRuiLi (adebrelimab)
21d
FASCINATE-N: Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy (clinicaltrials.gov)
P2, N=716, Recruiting, Fudan University | Trial completion date: Sep 2028 --> Sep 2029 | Trial primary completion date: Dec 2026 --> Dec 2027
Trial completion date • Trial primary completion date
|
HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • CD8 (cluster of differentiation 8) • FOXC1 (Forkhead Box C1)
|
Herceptin (trastuzumab) • carboplatin • Focus V (anlotinib) • Perjeta (pertuzumab) • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • Irene (pyrotinib) • albumin-bound paclitaxel • cyclophosphamide • letrozole • epirubicin • trastuzumab rezetecan (SHR-A1811) • AiRuiYi (fluzoparib) • Andewei (benmelstobart) • AiRuiKang (dalpiciclib) • goserelin acetate • famitinib (SHR 1020) • Idafang (ivonescimab) • bulumtatug fuvedotin (9MW2821) • AiRuiLi (adebrelimab) • IBI-354 • SHR-4602 • TQB2102 • TQB2868 • anbenitamab repodatecan (JSKN003) • tizetatug rezetecan (SHR-A1921)
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