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    DRUG:

    AiRuiKa (camrelizumab)

    i
    Other names: INCSHR-1210, SHR1210, HR301210, HR 301210, INCSHR 1210, SHR 1210, INCSHR1210, SHR-1210, HR-301210
    Company:
    CG Invites, HLB Bio Group, Jiangsu Hengrui Pharma, NPO Petrovax
    Drug class:
    PD1 inhibitor
    Related drugs:
    5d
    Nab-P+Cb+PD1 Inhibitors as Neoadjuvant Therapy for Early TNBC (clinicaltrials.gov)
    P2, N=64, Recruiting, Henan Cancer Hospital | Trial completion date: Nov 2025 --> May 2026 | Trial primary completion date: Nov 2025 --> May 2026
    Trial completion date • Trial primary completion date
    |
    carboplatin • AiRuiKa (camrelizumab)
    5d
    Locoregional gemcitabine plus surufatinib and camrelizumab in FGFR2-non-altered intrahepatic cholangiocarcinoma. (PubMed, Cell Rep Med)
    Exploratory analysis indicates that responders show significantly higher tumor PD-L1 expression than non-responders do, with median tumor proportion scores of 8% and 2%, respectively. The study is registered at ClinicalTrials.gov (NCT05236699).
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • FGFR2 (Fibroblast growth factor receptor 2)
    |
    PD-L1 expression
    |
    gemcitabine • AiRuiKa (camrelizumab) • Sulanda (surufatinib)
    7d
    Neoadjuvant Immune Checkpoint Inhibition in MSI-H/dMMR Colorectal Cancer: A Systematic Review of Prospective Trials Evaluating Efficacy, Pathologic Response, and Surgical Outcomes. (PubMed, J Gastrointest Cancer)
    Neoadjuvant immune checkpoint inhibition demonstrates high pathological and clinical response rates in dMMR/MSI-H colorectal cancer, with organ preservation achievable in selected rectal cancer patients. Neoadjuvant immunotherapy may become an alternative to surgery as the primary treatment for MSI-H/dMMR colorectal cancer if long-term quality of life is superior and toxicity and cost are competitive with standard surgical approaches. However, longer follow-up, predictive biomarkers, and randomized comparisons with upfront surgery are required before its routine clinical use.
    Review • Journal • Checkpoint inhibition • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • MSI-H • dMMR
    |
    MSI (Microsatellite instability)
    |
    MSI-H/dMMR
    |
    Opdivo (nivolumab) • Yervoy (ipilimumab) • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • Jemperli (dostarlimab-gxly)
    7d
    Infusional FOLFOX Plus Camrelizumab and Apatinib vs HAIC-FOLFOX Plus Camrelizumab and Apatinib for Advanced HCC (clinicaltrials.gov)
    P3, N=262, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | N=192 --> 262 | Trial completion date: Jul 2027 --> Jul 2029 | Trial primary completion date: Jul 2026 --> Jul 2028
    Enrollment change • Trial completion date • Trial primary completion date
    |
    5-fluorouracil • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • oxaliplatin • leucovorin calcium
    9d
    Clinical Efficacy Study of PD-1 Inhibitor Combined With Neoadjuvant Chemotherapy in Advanced Endometrial Cancer (clinicaltrials.gov)
    P2, N=39, Recruiting, Women's Hospital School Of Medicine Zhejiang University | Not yet recruiting --> Recruiting | Trial completion date: Dec 2029 --> Dec 2031 | Trial primary completion date: Sep 2029 --> Dec 2026
    Enrollment open • Trial completion date • Trial primary completion date
    |
    carboplatin • paclitaxel • AiRuiKa (camrelizumab)
    14d
    A Study of SYS6010, Enlonstobart, and Chemotherapy for First-Line Treatment of Esophageal Squamous Cell Carcinoma. (clinicaltrials.gov)
    P2/3, N=737, Not yet recruiting, CSPC Megalith Biopharmaceutical Co.,Ltd.
    New P2/3 trial • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    EGFR expression
    |
    cisplatin • paclitaxel • 5-fluorouracil • AiRuiKa (camrelizumab) • Tevimbra (tislelizumab-jsgr) • capecitabine • Enshuxing (enlonstobart) • SYS6010
    14d
    Chemo-immunotherapy for Cervical Cancer Stage IIICp Trial (clinicaltrials.gov)
    P2, N=0, Withdrawn, Women's Hospital School Of Medicine Zhejiang University | N=59 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    AiRuiKa (camrelizumab)
    19d
    PD-1 Inhibitor, Azacitidine and Low-dose DLI in AML Relapse After Allo-HSCT (clinicaltrials.gov)
    P=N/A, N=43, Recruiting, The First Affiliated Hospital of Soochow University | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Jul 2025 --> Jul 2026
    Trial completion date • Trial primary completion date
    |
    AiRuiKa (camrelizumab) • azacitidine
    20d
    Dalpiciclib Plus Camrelizumab for HCC Patients Who Have Previously Received ICI Treatment (clinicaltrials.gov)
    P2, N=30, Recruiting, Sun Yat-sen University
    New P2 trial • Checkpoint inhibition
    |
    AiRuiKa (camrelizumab) • AiRuiKang (dalpiciclib)
    21d
    Camrelizumab in Combination With Radiotherapy for Neoadjuvant Esophageal Carcinoma. (clinicaltrials.gov)
    P1/2, N=25, Active, not recruiting, Fujian Medical University Union Hospital | Recruiting --> Active, not recruiting | Trial completion date: Sep 2024 --> Nov 2026
    Enrollment closed • Trial completion date
    |
    AiRuiKa (camrelizumab)
    21d
    PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Salvage Locoregional Radiotherapy in De Novo Metastatic NPC (clinicaltrials.gov)
    P3, N=260, Recruiting, Sun Yat-sen University
    New P3 trial • Head-to-Head
    |
    cisplatin • AiRuiKa (camrelizumab) • Tevimbra (tislelizumab-jsgr)
    21d
    Combination of Carilizumab, Apatinib, and Radiotherapy for Advanced Mucosal Melanoma (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
    New P2 trial
    |
    AiRuiKa (camrelizumab) • AiTan (rivoceranib)