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    DRUG:

    amitriptyline

    Company:
    Generic mfg.
    Drug class:
    Norepinephrine reuptake inhibitor, Serotonin reuptake inhibitor
    Related drugs:
    5d
    The Treatment of Painful Diabetic Neuropathy With Diet (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, AdventHealth
    New trial
    |
    amitriptyline
    8d
    RCTVM: Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine (clinicaltrials.gov)
    P1, N=0, Withdrawn, Vanderbilt University Medical Center | N=100 --> 0 | Enrolling by invitation --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    amitriptyline
    2ms
    AHT: The influence of amitriptyline on human thermoregulation in young healthy adults (ACTRN12623001158651)
    P4, N=18, Completed, The University of Sydney | Recruiting --> Completed
    Trial completion
    |
    amitriptyline
    2ms
    Clinical trial to evaluate the effectiveness and efficiency of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT clinical trial. (2025-522967-13-00)
    P4, N=240, Not yet recruiting, Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz
    New P4 trial
    |
    SLC6A4 (Solute Carrier Family 6 Member 4) • HTR2A (5-Hydroxytryptamine Receptor 2A)
    |
    amitriptyline • imipramine
    3ms
    MACS-2: Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough (clinicaltrials.gov)
    P2, N=25, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Oct 2026 | Trial primary completion date: Dec 2025 --> Oct 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    3ms
    MACS-1: Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough (clinicaltrials.gov)
    P2, N=50, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    3ms
    MRP-HAND: Multiprofen-CC to Reduce Pain in Hand Arthritis (clinicaltrials.gov)
    P3, N=42, Not yet recruiting, McMaster University | Initiation date: Aug 2025 --> Jan 2026
    Trial initiation date
    |
    amitriptyline
    4ms
    TPS-Select: An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (clinicaltrials.gov)
    P3, N=126, Not yet recruiting, University of California, San Francisco
    New P3 trial
    |
    amitriptyline
    4ms
    Periosteal Osteosarcoma: Emerging Clinical Concepts, Evolving Treatment Options: A Narrative Review. (PubMed, Curr Pain Headache Rep)
    Adjuvant drugs can reduce inflammation and neuropathic pain, including corticosteroids, gabapentinoid agents such as gabapentin or pregabalin, lidocaine patches, tricyclic antidepressants such as amitriptyline, nortriptyline, and desipramine, or selective serotonin-norepinephrine reuptake inhibitors such as duloxetine and venlafaxine. The present investigation aims to synthesize currently available data on periosteal osteosarcomas, including common clinical, histologic, and radiographic presentations. In addition, this review aims to further examine the potential for biomarkers and provide recommendations for treatment and future research direction.
    Review • Journal
    |
    TP53 (Tumor protein P53)
    |
    TP53 mutation
    |
    amitriptyline
    7ms
    The Future of Oncology in Psychiatric Medications. (PubMed, J Clin Med)
    The anticancer potential of psychiatric drugs seems to be extremely broad, and the most extensive anticancer literature has been reported on antidepressants (fluoxetine, amitriptyline, imipramine, mirtazapine, and St John's Wort) and antipsychotics (chlorpromazine, pimozide, thioridazine, and trifluoperazine)...Among antidementia drugs, memantine has documented anticancer effects, while there is limited evidence for galantamine. Of the new psychiatric substances, the antipsychotic drug brexpiprazole and the antidepressant vortioxetine have a very interesting body of literature regarding glioblastoma, based on in vitro and in vivo animal survival studies...The anticancer properties of psychiatric drugs may prove particularly useful in the period between chemotherapy and radiotherapy sessions to maintain the tumor-inhibitory effect. While further research is necessary to elucidate the mechanisms, clinical implications, dose-dependence of the effect, and clear guidelines for the use of psychiatric medications in cancer therapy, the potential for these commonly prescribed medications to contribute to cancer treatment enhances their value in the management of patients facing the dual challenges of mental health and cancer.
    Journal
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SIRT1 (Sirtuin 1)
    |
    chlorpromazine • amitriptyline • fluoxetine • imipramine
    7ms
    Mind and Body Approaches to Pain Reduction in Youth With Migraine (clinicaltrials.gov)
    P2, N=132, Completed, Children's Hospital Medical Center, Cincinnati | Active, not recruiting --> Completed
    Trial completion
    |
    amitriptyline
    8ms
    TEC-ORL: Study to Evaluate the Interest of Qutenza in Patients With Head and Neck Cancer in Remission and With Sequelae Neuropathic Pain. (clinicaltrials.gov)
    P2, N=13, Completed, Institut Claudius Regaud | Active, not recruiting --> Completed | Trial completion date: Jan 2026 --> Apr 2025 | Trial primary completion date: Jan 2026 --> Apr 2025
    Trial completion • Trial completion date • Trial primary completion date
    |
    amitriptyline