These effects were associated with selective downregulation of Kir6.2 and the mitochondrial KATP-associated component CCDC51, impaired autophagic flux with p62 accumulation, and robust activation of executioner caspases. In conclusion, MitoQ may induce mitochondrial dysfunction in metabolically primed GBM cells, and cellular sensitivity appears to correlate with a distinct KATP channel expression signature.

IDE significantly improved UVB-induced photoaging damage in HaCaT cells through multiple pathways, including restoring cell viability, alleviating oxidative stress damage, reducing pro-inflammatory factor infiltration, and protecting mitochondrial function. Its mechanism of action may involve the regulation of targets such as IL-3RA and TUBA8.

P1/2, N=153, Not yet recruiting, PLL TX AUSTRALIA PTY LTD | Trial completion date: Dec 2026 --> Jun 2027

Co-administration of ASA markedly mitigated these biochemical and histopathological alterations, normalizing antioxidant defenses and downregulating inflammatory mediators and NF-κB activation. The obtained results suggest that ASA is not toxic in this context and may actually protect against the liver and brain damage caused by IMID by dampening the oxidative stress and inflammatory responses driven by HMGB1 and NF-κB.

These findings suggest that Visomitin exerts potent anti-leukemic effects by simultaneously promoting differentiation and apoptosis through ROS-mediated SYK inhibition. The selective activity against malignant cells and favorable in vivo efficacy suggest that Visomitin is a potential therapeutic agent for AML.

P=N/A, N=20, Completed, University of California, Davis | Recruiting --> Completed

However, in participants ≥70 years of age, we observed possible evidence of efficacy of MitoQ supplementation for improving select measures of strength. Future clinical trials with MitoQ and possibly other mitochondria-targeted antioxidant approaches for enhancing physical function with ageing should focus on older adults of more advanced age or more frail clinical populations.

P2, N=33, Completed, University of Minnesota | Recruiting --> Completed | N=50 --> 33

P=N/A, N=0, Withdrawn, University-Town Hospital of Chongqing Medical University | N=38646 --> 0 | Completed --> Withdrawn

P1/2, N=25, Not yet recruiting, University of Arizona

P=N/A, N=86, Not yet recruiting, Colorado State University

P1, N=10, Not yet recruiting, University of Texas Southwestern Medical Center