In addition, BLPs-SeNPs showed stronger inhibitory and pro-apoptotic effects on tumor cells than BLPs alone. Overall, these results indicate that BLPs can serve as effective natural stabilizers for selenium nanoparticles and that the resulting BLPs-SeNPs possess promising in vitro bioactivities.

The present study investigates the anticancer therapeutic potential of two MTAs, MitoQ, and Mito-TEMPO, in rodent N-nitrosodiethylamine-induced hepatic cancer...The combination treatment of these two MTAs also exhibited additive anticancer therapeutic potential on tumor profile. Therefore, MTA-based anticancer therapy approach holds a promising future.

Immunofluorescence further revealed that PASN rescued the expression of brain-derived neurotrophic factor (BDNF) (hACs: 35.23%, PC12: 12.50%) and glutamate decarboxylase (GAD1/2) (hACs: 102.66%, PC12: 31.31%), key markers associated with synaptic plasticity and GABAergic sleep regulation. Collectively, PASN is a thermally stable squid-derived peptide fraction that exerts antioxidant and cytoprotective effects in neural cell models in vitro and represents a promising sustainable candidate for nutraceutical development.

Critically, while zileuton remains the sole clinically approved lipoxygenase-targeting drug, it is clinically used as a 5-LOX inhibitor for asthma and is not an h15-LOX-2-targeted therapy...Outstanding challenges including the scarcity of ex vivo validated compounds, species-specific translational barriers arising from divergent murine ortholog function, and the absence of wild-type inhibitor co-crystal structures are critically evaluated. Future directions encompassing covalent inhibitor strategies, PROTAC-based targeted degradation, and selective modulation of the pro-ferroptotic h15-LOX-2/PEBP1 complex are discussed as promising avenues to fully realize the therapeutic potential of this target.

Here, we found that two antioxidants, glutathione (GSH) and N-acetylcysteine (NAC), stabilized BACH1 (i.e., BTB and CNC homology 1) by decreasing ROS levels, thus facilitated BACH1-dependent migration of HCC cells in vitro and their metastasis in vivo...The BACH1-regulated metabolic reprogramming was further unraveled by non-targeted metabolomics. Collectively, these demonstrate that the redox-sensitive transcription factor BACH1 functions as a crucial metastasis-promoter of HCC, and thus antioxidants stimulate BACH1-dependent HCC metastasis.

These observations imply an increased solubilization and elastovesicular behaviour of spanlastic nanoparticles with enhanced bioactivity of rutin. In conclusion, rutin spanlastic nanoparticles are an efficient delivery vehicle compared to rutin nanocrystals or free rutin in amplifying both antioxidant and anticancer activity, hence warranting further in vivo experiments to treat breast carcinoma.

MIC and MBC were > 5 mg mL-1 for all strains and showed no antibacterial activity at the tested concentrations. However, the extract of Piper corcovadensis exhibits significant in vitro bioactivity, particularly in antioxidant capacity, modulation of oxidative stress markers, and effects on melanoma cell viability.

P2, N=25, Completed, Children's Hospital Medical Center, Cincinnati | Active, not recruiting --> Completed | N=58 --> 25

Docking studies revealed a high affinity of APG for key proteins regulating antioxidant activity, apoptotic pathways, and inflammatory responses. In conclusion, APG-PCHNPs provided superior protection against DLM-induced liver injury by enhancing antioxidant defenses, suppressing NF-κB-mediated inflammation, and modulating Bcl-2/Bax/Caspase-3 signaling to prevent apoptosis, outperforming crude APG due to improved stability, solubility, and bioavailability.

Gene expression analysis revealed downregulation of tumor necrosis factor-alpha and interleukin-6, alongside strong upregulation of the anti-inflammatory cytokine interleukin-10 (2.1-fold) at 25-50 % SWPM, whereas 75 % inclusion induced pro-inflammatory signaling. In conclusion, dietary inclusion of 25-50 % SWPM combined with probiotics is optimal for enhancing growth, antioxidant defense, digestive efficiency, and immune homeostasis in P. pangasius, supporting its use in sustainable functional aquafeeds.

Comprehensive analysis revealed that SeP demonstrated superior overall efficacy compared to Na2SeO3 in enhancing growth performance, boosting antioxidant and immune functions, and suppressing PCV2 replication. This study provides a theoretical basis for employing SeP as a precise nutritional strategy in pig populations affected by PCV2.

In conclusion, dietary antioxidants should be considered as modulators of redox-sensitive signaling networks, not merely as simple radical scavengers. Personalized modulation of redox homeostasis is a future strategy for cancer prevention, with a greater emphasis on whole-diet and biomarker-guided approaches.