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    CANCER:

    Basal Cell Carcinoma

    Related cancers:
    2d
    Ber-EP4 Expression and Staining Patterns in Cutaneous Basal Cell Carcinoma: A Clinicopathological Study From a Vietnamese Cohort. (PubMed, Am J Dermatopathol)
    Ber-EP4 is a highly sensitive immunohistochemical marker for cutaneous BCC, showing predominantly diffuse expression across diverse clinicohistologic contexts. However, reduced expression in ulcerated tumors and the presence of nondiffuse staining patterns highlight potential diagnostic pitfalls, particularly in superficially sampled lesions. These findings underscore the need for cautious interpretation and integrated histomorphological and immunohistochemical assessment to ensure diagnostic accuracy.
    Journal
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    EPCAM (Epithelial cell adhesion molecule)
    7d
    The Purpose of This Study is to Evaluate the Safety and Efficacy of D-MNA in Adult Patients With Nodular Basal Cell Carcinoma (clinicaltrials.gov)
    P2, N=90, Completed, SkinJect, Inc. | Recruiting --> Completed | N=60 --> 90 | Trial completion date: Jun 2025 --> Mar 2026 | Trial primary completion date: Feb 2025 --> Mar 2026
    Trial completion • Enrollment change • Trial completion date • Trial primary completion date
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    doxorubicin hydrochloride
    9d
    Multiplexed Immunofluorescent Characterization of T-Cell and Myeloid Cell Populations Reveals Histologic Subtype Differences Within the Immunosuppressive Landscape of Human Basal Cell Carcinoma. (PubMed, J Cutan Pathol)
    The association of infiltrative BCC with a more immunosuppressed microenvironment may contribute to more aggressive biological behavior. Overall, these data demonstrate a method to determine T cell and myeloid profiles in fixed FFPE skin tumor tissues that can identify subtle immune profile differences.
    Journal
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD163 (CD163 Molecule) • CD4 (CD4 Molecule) • CD68 (CD68 Molecule) • FOXP3 (Forkhead Box P3) • CD1C (CD1c Molecule)
    10d
    RELI: Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice (clinicaltrials.gov)
    P=N/A, N=297, Not yet recruiting, Maastricht University Medical Center
    New trial • HEOR • Real-world evidence
    10d
    LEAH: Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals (clinicaltrials.gov)
    P=N/A, N=5909, Recruiting, Gustave Roussy, Cancer Campus, Grand Paris | Not yet recruiting --> Recruiting
    Enrollment open
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    TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • STK11 (Serine/threonine kinase 11) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • POLE (DNA Polymerase Epsilon) • RUNX1 (RUNX Family Transcription Factor 1) • BAP1 (BRCA1 Associated Protein 1) • ETV6 (ETS Variant Transcription Factor 6) • MLH1 (MutL homolog 1) • CDK4 (Cyclin-dependent kinase 4) • MSH2 (MutS Homolog 2) • SMAD4 (SMAD family member 4) • CDH1 (Cadherin 1) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • POLD1 (DNA Polymerase Delta 1) • RAD51C (RAD51 paralog C) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • RAD51D (RAD51 paralog D) • DDX41 (DEAD-Box Helicase 41) • GATA2 (GATA Binding Protein 2) • DICER1 (Dicer 1 Ribonuclease III) • FLCN (Folliculin) • PRSS1 (Serine Protease 1) • SDHD (Succinate Dehydrogenase Complex Subunit D) • TXNIP (Thioredoxin Interacting Protein) • ANKRD26 (Ankyrin Repeat Domain Containing 26) • BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) • HOXB13 (Homeobox B13)
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    TP53 mutation • PTEN deletion
    13d
    LANCE: FLASH Radiotherapy for Skin Cancer (clinicaltrials.gov)
    P=N/A, N=60, Active, not recruiting, Centre Hospitalier Universitaire Vaudois | Recruiting --> Active, not recruiting | Trial completion date: Sep 2026 --> May 2026 | Trial primary completion date: Sep 2026 --> May 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    13d
    Locus- and Gene-Level Insights into the Inverse Association Between Alzheimer's Disease and Cancer. (PubMed, Int J Mol Sci)
    Across cancer types, genes inversely associated with AD converged on pathways involved in cell cycle regulation, apoptosis, DNA-damage response, and metabolic processes. These results support the hypothesis that biological mechanisms promoting proliferation and survival in cancer may oppose those contributing to neurodegeneration in AD.
    Journal
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    APOE (Apolipoprotein E)
    13d
    The Role of the TG2-GPR56 Complex in Cutaneous Squamous Cell Carcinoma (CSCC) Aggression and Therapeutic Resistance. (PubMed, Int J Mol Sci)
    This molecular axis is particularly significant for its role in the maintenance of epidermal cancer stem (ECS) cells, which contribute to tumor progression and therapy resistance. While the definitive link between the TG2-GPR56 complex and systemic metastasis in cSCC is currently being elucidated, significant evidence from analogous malignancies and in vitro keratinocyte models provides a clear mechanistic roadmap for its involvement in tumor invasion.
    Review • Journal
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    TGM2 (Transglutaminase 2) • ADGRG1 (Adhesion G Protein-Coupled Receptor G1)
    14d
    Pediatric Skin Cancer: Melanoma, Basal and Squamous Cell Carcinomas, and Dermatofibrosarcoma Protuberans. (PubMed, J Dermatol)
    Considering the pediatric-specific factors common to these malignancies, individualized treatment approaches are required. This review integrates the latest findings in molecular pathology and clinical guidelines to support accurate diagnosis, treatment, and follow-up in pediatric dermatology.
    Review • Journal
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    BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog) • COL1A1 (Collagen Type I Alpha 1 Chain) • PDGFB (Platelet Derived Growth Factor Subunit B)
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    BRAF mutation • NRAS mutation
    15d
    Genetic Insight into Gorlin-Goltz Syndrome. (PubMed, Indian J Dermatol)
    The gene mutated also determines the phenotypic expression of the syndrome. Detection of the gene mutated plays an important role in, antenatal diagnosis, confirming the diagnosis when in doubt clinically and predictive diagnosis in family members of the affected individuals, which helps us to diagnose the syndrome early, hence screen for various clinical manifestations at the appropriate age according to the gene that is mutated and initiate early treatment to reduce morbidity and mortality.
    Journal
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    PTCH1 (Patched 1)
    16d
    An exceptional perianal basal cell carcinoma with follicular differentiation mimicking Hemorrhoids: a rare case report. (PubMed, Oxf Med Case Reports)
    This case highlights the diagnostic challenge of perianal BCC mimicking benign lesions and emphasizes the need for histopathological confirmation. Follicular differentiation is exceptionally uncommon and should be distinguished from adnexal tumors such as trichoblastic carcinoma.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • TP63 (Tumor protein 63)