Basal Cell Carcinoma

In this review, we present the current therapeutic opportunities and future directions of immunotherapy in the management of malignant melanoma, cutaneous squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma, accompanied by a brief overview of their mechanisms of action. Ambrus L, Balatoni T. Immunotherapy of cutaneous neoplasms.

As Professor Sydney Gellis remarked, 'When he gets down to the ovaries, he's gone about as far as he can go', capturing Gorlin's expansive curiosity and expertise. As well as the legacy of the syndromes he has been associated with, he has left a blueprint for all clinical colleagues to take forward in their daily practice - empathy, humour and generosity of spirit.

Elevated risk for the development of SC has been identified with underlying immunosuppression, as seen in similar studies. Histopathological examination remains crucial for accurate diagnosis and management.

Although the term 'rodent ulcer' has largely been replaced by 'basal cell carcinoma', the historical term still appears in some clinical and historical contexts. This evolution reflects broader trends in medicine, transitioning from symptom-based descriptors to molecularly informed classifications, marking the ongoing development of medical science.

S100, SOX10, neurofilament and desmin are typically negative. While perineuriomas behave in a benign fashion, complete surgical excision is recommended.

HPV8 AKs were more prevalent in immunosuppressed patients (odds ratio 3.33, P = 0.05); however, immunosuppression did not add to the risk of subsequent SCC. Immunosuppression greatly increases the risk of HPV8-associated AKs and therefore KC.

Gli2-dominant Hh overexpression was seen in the tumour plus stroma of eyelid morphoeic but not nodular BCC. FLNB is a potential tumour suppressor, with its loss producing a morphoeic phenotype in vitro.

PCS remains a diagnostic and therapeutic challenge due to its rarity and lack of standardized guidelines. This study highlights the importance of histopathology, IHC, and multidisciplinary management.

P1, N=56, Recruiting, Memorial Sloan Kettering Cancer Center | Active, not recruiting --> Recruiting

This review consolidates existing evidence and suggests that mixed cancer syndromes, especially LFS, LS, and HBOC but also pathogenic ATM and CHEK2 variants may predispose individuals to skin cancers, warranting tailored screening and preventive measures. On the basis of emerging evidence, we recommend dermatologic evaluation and individualized UV protection strategies for patients with reviewed hereditary cancer syndromes to reduce skin cancer risk and enhance early detection.

In addition, TRPS1 exhibited higher AUC values than GATA3 and adipophilin in differentiating primary and recurrent SCs, although the difference was not significant. Collectively, our findings indicate that the TRPS1/GATA3/adipophilin-based model demonstrated excellent discriminatory efficacy for eyelid malignancies (Kappa = 0.784, micro-average F1 = 0.882, AUC-ROC = 0.964 [95%CI:0.934-0.994]), achieving clinical-grade performance.

Our findings suggest that CA-IX is strongly expressed in periocular BCC tissues and may also serve as a systemic marker, given its elevated serum levels. The lower levels of antioxidant enzymes may be an indicator of possible systemic oxidative stress in BCC patients.