BCL2 (B-cell CLL/lymphoma 2)

P3, N=156, Not yet recruiting, Ruijin Hospital

Additionally, the OHCC potentiated the antiproliferative effect of doxorubicin, as evidenced by a raised Bax/Bcl-2 ratio and caspase 9 content, and suppressed VEGF levels...The histopathological investigation supported the apoptotic and necrotic death of cancer cells. These findings suggest that HCCs represent a promising nanocarrier system for the targeted parenteral delivery of FEL in cancer therapy.

Virtual screening and molecular dynamics simulations identified acetyldigitoxin (ADT) as a potent EZH2 inhibitor, demonstrating superior binding affinity (-10.90 kcal/mol) and complex stability compared to the known inhibitor GSK126...ADT induced G0/G1 cell cycle arrest and promoted apoptosis, accompanied by upregulation of pro-apoptotic genes (Bax, Caspase-3) and downregulation of anti-apoptotic (Bcl-2) and cell cycle (CyclinD1) genes. Our integrated findings position ADT as a repurposed drug candidate for targeting EZH2 in NSCLC, warranting further preclinical investigation including direct enzyme inhibition assays.

Surgical margins were negative, and one-year follow-up showed that the patient remained disease-free. This case highlights the importance of immunohistochemistry and molecular testing for accurate diagnosis and appropriate management.

Synergistic effects with bortezomib (BTZ) were analyzed...SNG exerts potent anticancer effects in CTCL by inducing ROS-dependent mitochondrial apoptosis and inhibiting the PI3K/AKT/GSK3 signaling pathway. Its synergy with BTZ and computational validation of AKT/Bcl-2 targeting underscore its potential as a novel therapeutic candidate for CTCL, warranting further preclinical investigation.

The present study suggests that SPINK1 may modulate glycolytic metabolism in lung cancer cells, inhibiting their growth and proliferation, and potentially providing therapeutic insights.

GA markedly inhibits proliferation, migration, and induces apoptosis in OS cells primarily by regulating the glycolytic pathway, i.e., reduction in lactate levels, subsequent targeting of KAT2A, downregulation of H3K18 lactylation, and ultimate transcriptional regulation of apoptosis. It is hereby recognized that GA mediates metabolic inhibition by selective epigenetic reprogramming of the KAT2A-H3K18 lactylation axis. The current findings establish histone lactylation as a key mechanism in OS inhibition and highlight metabolicepigenetic cross-talk as a promising therapeutic regimen for aggressive bone malignancies.

The patient was treated with six cycles of rituximab-bendamustine, resulting in complete regression of the nasopharyngeal mass and reduction in splenomegaly, with minimal residual lymphadenopathy and good clinical and biological tolerance. This case highlights the importance of considering CLL in the differential diagnosis of nasopharyngeal masses and emphasizes the role of combined imaging, histology, and immunophenotyping in establishing an accurate diagnosis and guiding appropriate management.

Silibinin potentiates paclitaxel cytotoxicity by suppressing H19 transcription, offering a potential strategy to overcome paclitaxel resistance. The combination promotes apoptosis via caspase activation, highlighting a novel synergistic therapeutic approach in breast cancer treatment.

Silymarin also reduced Caspase-3 levels while increasing Bcl-2 protein expression, an antiapoptotic protein. These results suggest that silymarin has significant therapeutic potential for reducing Paclitaxel-induced cardiotoxicity via its antioxidant, anti-inflammatory, and anti-apoptotic properties.

RES also suppressed IL-6, IL-8, TNF-α, and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) expression, and enhanced anti-apoptotic genes B-cell lymphoma-extra-large and B-cell lymphoma 2 expression (P < 0.05). In conclusion, RES supplementation (400 mg/kg) effectively improved laying performance, egg quality, and oxidative and inflammatory responses in laying hens, suggesting its potential as a nutritional strategy to support laying performance during the late production stages.

Patchouli alcohol (PA) is a tricyclic sesquiterpene derived from Pogostemon cablin, and the present study evaluated the antihepatoma capacity of PA and described a potential strategy for its combination with sorafenib (SOR) in vitro and in vivo...On the whole, PA alone or in combination with SOR exhibited markedly improved therapeutic efficacy in HCC by blocking AR-mediated and multiple other signaling pathways. Therefore, this study provides an experimental basis for the evaluation of PA as an alternative drug (alone or in combination) for the treatment of HCC.