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    DRUG CLASS:

    BCMA-targeted CAR-T immunotherapy

    Related drugs:
    2d
    Safety and Efficacy of RN1201 Injection as First-Line Treatment for Newly Diagnosed Multiple Myeloma (clinicaltrials.gov)
    P1, N=18, Recruiting, The First Affiliated Hospital of Soochow University
    New P1 trial
    7d
    RN1201 Injection in the Treatment of Antibody-Mediated Diseases (clinicaltrials.gov)
    P1, N=9, Recruiting, The First Affiliated Hospital of Soochow University | Not yet recruiting --> Recruiting
    Enrollment open
    7d
    CADMIUM: Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma (clinicaltrials.gov)
    P2, N=78, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended
    Trial suspension
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    Abecma (idecabtagene vicleucel) • iberdomide (CC-220)
    7d
    Product-Intrinsic NF-κB-Driven Transcriptional Programs Connote Durability of CAR-T Response in Multiple Myeloma. (PubMed, Blood)
    Finally, validating functional relevance, pharmacologic inhibition of NF-κB abrogated CAR-T cytotoxicity and cytokine production in vitro. Our results support that NFKB in the ide-cel product marks a signaling axis impacting CAR-T function and NFKB activity represents a global marker of T cell fitness present prior to CAR-T manufacture.
    Journal • IO biomarker
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    CD4 (CD4 Molecule)
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    Abecma (idecabtagene vicleucel)
    7d
    A novel triple-knockout allogeneic BCMA CAR T cell therapy (CT0590) in multiple myeloma: preclinical and phase I study. (PubMed, Blood)
    These results suggest that CAR-NKG2A technology may overcome HvGR, especially in patients with elevated NKG2A expression on NK cells. Further studies of CT0590 in RRMM and pPCL are warranted.
    P1 data • Preclinical • Journal • IO biomarker • First-in-human
    |
    KLRC1 (Killer Cell Lectin Like Receptor C1)
    8d
    Multiple Myeloma Cells Resistant to T-cell Therapies Exhibits a CD45+ Immune Evasive Phenotype. (PubMed, Cancer Immunol Res)
    Bone marrow samples were treated ex vivo with BCMA CAR T cells, TCEs (elranatamab, SAR442257), or activated T cells, and analyzed by flow cytometry. CD45 upregulation was validated in patient samples before and after idecabtagene vicleucel therapy (anti-BCMA CAR T-cell therapy), and by using in an in vivo mouse model of disseminated MM...Mechanistic studies implicated secreted HSP70, while bulk RNA-sequencing revealed increased LAG-3, IFN-γ signaling, and PD-L1 expression. These findings suggest T cell-redirecting therapy (TCRT) drives an immuno-evasive phenotype defined by CD45 upregulation and immune checkpoint activation, supporting combination strategies of TCRT with checkpoint inhibitors to overcome resistance in relapsed/refractory MM.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C)
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    PD-L1 expression
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    Elrexfio (elranatamab-bcmm) • SAR442257 • Abecma (idecabtagene vicleucel)
    8d
    EMN2868284528MMY3005: A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (2023-507632-20-00)
    P2/3, N=440, Recruiting, European Myeloma Network B.V., Emn Trial Office S.r.l. Impresa Sociale | Not yet recruiting --> Recruiting
    Enrollment open
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    lenalidomide • bortezomib • Darzalex (daratumumab) • dexamethasone • Carvykti (ciltacabtagene autoleucel)
    8d
    Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) (clinicaltrials.gov)
    P1, N=52, Recruiting, Washington University School of Medicine | Not yet recruiting --> Recruiting
    Enrollment open
    |
    clonoSEQ®
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    Carvykti (ciltacabtagene autoleucel) • Hyleukin-7 (efineptakin alfa)
    9d
    A Study of GC012F Injection in Subjects With Refractory Systemic Lupus Erythematosus (clinicaltrials.gov)
    P1/2, N=20, Active, not recruiting, Gracell Biotechnologies (Shanghai) Co., Ltd. | Recruiting --> Active, not recruiting | N=118 --> 20
    Enrollment closed • Enrollment change
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    AZD0120
    14d
    Autologous BCMA-targeted CAR-T Cell Injection for Relapsed/Refractory Light Chain Amyloidosis (clinicaltrials.gov)
    P1, N=30, Recruiting, Beijing Boren Hospital
    New P1 trial
    16d
    Exploratory Clinical Trial of DQ1001 in Relapsed or Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov)
    P1, N=16, Not yet recruiting, Zhongshan Hospital (Xiamen), Fudan University
    New P1 trial
    |
    GPRC5D (G Protein-Coupled Receptor Class C Group 5 Member D)
    |
    cyclophosphamide • fludarabine IV
    16d
    D8311C00001: A trial to learn how well AZD0120 works and how safe it is in people with relapsed or refractory multiple myeloma. (2025-523285-25-00)
    P2/3, N=153, Not yet recruiting, AstraZeneca AB | N=38 --> 153
    Enrollment change
    |
    bortezomib • Darzalex (daratumumab) • carfilzomib • pomalidomide • AZD0120