TET and TMZ significantly reduced pro-MMP-2 levels in M010b cells under both conditions and in U87 cells under normoxia. In conclusion, given the limited therapeutic potential of TMZ, our findings suggest that TET could be a viable alternative treatment option for GBM.

7 days ago

Journal

MMP2 (Matrix metallopeptidase 2)

temozolomide • CBT-1 (tetrandrine)

NEPHRON: Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (clinicaltrials.gov)

P=N/A, N=200, Recruiting, The Cleveland Clinic | Not yet recruiting --> Recruiting

7 days ago

Enrollment open

11d

Design, Synthesis, and Biological Evaluation of Novel Tetrandrine Derivatives Targeting AKT1 for Hepatocellular Carcinoma Therapy: Integration of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation. (PubMed, ACS Omega)

Compound 17 exhibited the strongest cytotoxic effect against HepG2 cells with an IC50 value of 2.09 μM and a satisfactory SI value of 11.5, which was 5.3- and 6.4-fold higher than the activity of parental tetrandrine and adriamycin, respectively. Moreover, it indicates a potent in vivo killing effect against liver cancers, orthotopically transplanted HCC in an AKT1-dependent manner, with a safety profile. Taken together, compound 17 shows therapeutic potential as a safe anticancer agent through apoptosis induction, worthy of further development.

11 days ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CASP3 (Caspase 3)

doxorubicin hydrochloride • CBT-1 (tetrandrine)

17d

Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy (clinicaltrials.gov)

P1/2, N=60, Recruiting, Mayo Clinic | Not yet recruiting --> Recruiting

17 days ago

Enrollment open

capecitabine • fluorouracil topical

22d

PERVADE-ED: PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department (clinicaltrials.gov)

P=N/A, N=20, Recruiting, University of Iowa | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Jun 2026 --> Jun 2027

22 days ago

Trial completion date • Trial primary completion date

23d

Zonisamide Versus Topiramate in Migraine (clinicaltrials.gov)

P3, N=600, Completed, Kafrelsheikh University | Recruiting --> Completed | Trial completion date: May 2025 --> Apr 2026 | Trial primary completion date: Apr 2025 --> Apr 2026

23 days ago

Trial completion • Trial completion date • Trial primary completion date

27d

Chemical components from Uncaria gambir (W.Hunter) Roxb. and their preliminary bioactivities in CDC25B phosphatase inhibition and vasodilatory activity. (PubMed, Nat Prod Res)

Compound 3 (3α-dihydrocadambine) effectively revealed strong vasodilatory activity with EC50 values of 2.4 μM and 2.1 μM, respectively, similar levels comparable to the positive control (verapamil)...Moreover, network pharmacology and molecular docking predicted compound 1 to correlate with the p53-Hippo-TGF-β antitumor signalling pathway and compound 3 with the cAMP/cGMP-PKG cardiovascular signalling pathway. This work provides preliminary experimental data for the development of potential lead compounds from U. gambir.

27 days ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)

27d

Tetrandrine-based in situ vaccination via multifunctional Mn²⁺-hyaluronic acid hydrogel loading gelatinase-responsive nanoparticles. (PubMed, J Nanobiotechnology)

Bulk and single-cell transcriptomic analyses further revealed complement-associated activation, extracellular-matrix remodeling, and enrichment of antigen-presenting and inflammatory macrophage programs. Thus, TETNPs@Gel functions as an in situ nanovaccine rather than a conventional cytotoxic formulation, in which controlled tetrandrine release couples direct tumor-cell killing with vascular and immune re-education, offering a potentially generalizable platform for localized immunochemotherapy in solid tumors.

27 days ago

Journal

CD8 (cluster of differentiation 8)

CBT-1 (tetrandrine)

Ver-A-T1D: Verapamil SR in Adults With Type 1 Diabetes (clinicaltrials.gov)

P2, N=136, Completed, Medical University of Graz | Active, not recruiting --> Completed

1 month ago

Trial completion

Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia (clinicaltrials.gov)

P3, N=130, Completed, Milestone Pharmaceuticals Inc. | Enrolling by invitation --> Completed

1 month ago

Trial completion

A Single-Arm, Prospective Study of Papaverine for the Treatment of Refractory Peripheral Neuropathy Induced by Taxane-Based Chemotherapy (clinicaltrials.gov)

P=N/A, N=43, Not yet recruiting, Second Affiliated Hospital, School of Medicine, Zhejiang University

1 month ago

New trial

papaverine