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    DRUG CLASS:

    CD52 inhibitor

    Related drugs:
    1d
    Targeting the cytokine storm: new therapies in the treatment of paediatric haemophagocytic lymphohistiocytosis. (PubMed, Expert Rev Clin Immunol)
    Emapalumab, alemtuzumab and ruxolitinib show promising results, however widespread use is limited by small, non-randomized trials in a heterogenous population. Further international collaborative efforts to develop clinical trials to put conventional chemotherapy treatments head-to-head with these newer therapies is critical for advancement of these agents.
    Review • Journal
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    IFNG (Interferon, gamma)
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    Jakafi (ruxolitinib) • Campath (alemtuzumab)
    1d
    A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients (clinicaltrials.gov)
    P3, N=10, Completed, Northwestern University | N=40 --> 10 | Active, not recruiting --> Completed
    Trial completion • Enrollment change
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    Campath (alemtuzumab)
    9d
    CD48 expression in T-lymphoblastic leukemia/lymphoma and mature T-cell neoplasms: role in detecting measurable residual disease and potential confounders, a single-institution retrospective review. (PubMed, Am J Clin Pathol)
    CD48 expression is diminished compared with normal background T cells in most cases of T-ALL at diagnosis and posttherapy, whereas it was typically retained in mature T-cell/natural killer-cell neoplasms. While CD48 levels may fluctuate after chemotherapy in T-ALL, reduced CD48 can be used as a marker of immaturity in most MRD cases. Potential confounders in the assessment of CD48 include alemtuzumab therapy and the presence of GPI-deficient populations.
    Retrospective data • Journal
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    CD48 (CD48 Molecule)
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    Campath (alemtuzumab)
    18d
    Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease (clinicaltrials.gov)
    P2, N=45, Not yet recruiting, St. Jude Children's Research Hospital
    New P2 trial
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    cyclophosphamide • Campath (alemtuzumab) • sirolimus • hydroxyurea • thiotepa • Neupogen (filgrastim) • Orencia (abatacept)
    21d
    LEMTRADA Pregnancy Registry in Multiple Sclerosis (clinicaltrials.gov)
    P=N/A, N=42, Completed, Genzyme, a Sanofi Company | Terminated --> Completed
    Trial completion
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    Lemtrada (alemtuzumab)
    1m
    Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors (clinicaltrials.gov)
    P1/2, N=90, Recruiting, National Heart, Lung, and Blood Institute (NHLBI)
    New P1/2 trial
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    Campath (alemtuzumab) • Orencia (abatacept)
    2ms
    First-in-Human Study of IL15-Activated Cytokine-Induced Killer Cells After Allogeneic HCT Shows Durable Remission and Serotherapy-Associated Immune Reconstitution in Leukemia. (PubMed, J Clin Oncol)
    IL15-CIK monotherapy is feasible and safe and demonstrates promising relapse-preventive activity after hematopoietic stem-cell transplantation. Clinical outcomes are strongly influenced by disease burden at treatment initiation and previous serotherapy, supporting optimized patient selection and timing in future post-transplant immunotherapeutic strategies.
    P1 data • Journal • First-in-human
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    IL15 (Interleukin 15)
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    Campath (alemtuzumab)
    3ms
    Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita (clinicaltrials.gov)
    P2, N=40, Active, not recruiting, Boston Children's Hospital | Trial primary completion date: Jul 2026 --> Dec 2026
    Trial primary completion date
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    TERT (Telomerase Reverse Transcriptase) • HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • DKC1 (Dyskerin Pseudouridine Synthase 1) • ZCCHC8 (Zinc Finger CCHC-Type Containing 8) • HLA-C (Major Histocompatibility Complex, Class I, C)
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    Campath (alemtuzumab) • fludarabine IV • cyclosporin A microemulsion
    4ms
    ADAs to Alemtuzumab (clinicaltrials.gov)
    P=N/A, N=15, Completed, Queen Mary University of London | Active, not recruiting --> Completed
    Trial completion
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    Lemtrada (alemtuzumab)
    4ms
    A Unique Case of Concomitant T-Prolymphocytic Leukemia and B-Cell Acute Lymphoblastic Leukemia. (PubMed, EJHaem)
    One proposed mechanism for the development of both hematologic malignancies in this patient is the acquisition of a KMT2A rearrangement, raising the possibility of clonal evolution resulting in therapy-related or secondary leukemia. Another explanation is the presence of a common clonal stem cell progenitor harboring a JAK3 mutation.
    Journal
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    KMT2A (Lysine Methyltransferase 2A) • JAK3 (Janus Kinase 3)
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    KMT2A rearrangement
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    Campath (alemtuzumab)
    4ms
    Immune Disorder HSCT Protocol (clinicaltrials.gov)
    P2, N=20, Active, not recruiting, Washington University School of Medicine | Recruiting --> Active, not recruiting | Trial completion date: Mar 2027 --> Apr 2026 | Trial primary completion date: Mar 2027 --> Apr 2025
    Enrollment closed • Trial completion date • Trial primary completion date
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    Campath (alemtuzumab) • melphalan • fludarabine IV • thiotepa