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DRUG CLASS:

CDK4 inhibitor

12h
New P1/2 trial
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fulvestrant • letrozole
15h
Trial completion date • Trial primary completion date • First-in-human
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HER-2 (Human epidermal growth factor receptor 2)
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HER-2 negative
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giredestrant (RG6171) • omeprazole
3d
New P3 trial
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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ER positive • HR positive • HER-2 negative • HER-2 expression • HER-2 underexpression • PGR positive
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trastuzumab rezetecan (SHR-A1811) • famitinib (SHR 1020)
3d
MONARCH 3: A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer (clinicaltrials.gov)
P3, N=493, Active, not recruiting, Eli Lilly and Company | Trial completion date: Dec 2025 --> Dec 2026
Trial completion date
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HER-2 (Human epidermal growth factor receptor 2)
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HR positive • HER-2 negative
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Verzenio (abemaciclib) • letrozole • anastrozole
6d
New trial
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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HR positive • HER-2 negative
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fulvestrant • Jingzhuda (entinostat)
9d
Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer (clinicaltrials.gov)
P2, N=28, Recruiting, The Methodist Hospital Research Institute | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Dec 2026
Trial completion date • Trial primary completion date
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
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ER positive • HER-2 negative • HER-2 negative + ER positive
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Verzenio (abemaciclib) • fulvestrant
11d
New P2 trial • Circulating tumor DNA
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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ER positive • HR positive • HER-2 negative • HER-2 negative + AR positive + ER positive • HER-2 negative + ER positive
14d
New P1 trial
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HER-2 (Human epidermal growth factor receptor 2)
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HR positive • HER-2 negative
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fulvestrant • letrozole
16d
Enrollment open
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ER (Estrogen receptor) • PGR (Progesterone receptor)
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HER-2 positive • ER positive • HER-2 amplification • PGR positive
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tamoxifen • letrozole • exemestane
21d
postMONARCH: Abemaciclib (LY2835219) Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer (clinicaltrials.gov)
P3, N=368, Active, not recruiting, Eli Lilly and Company | Trial completion date: Feb 2026 --> Dec 2027
Trial completion date
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HER-2 (Human epidermal growth factor receptor 2)
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HER-2 negative
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Verzenio (abemaciclib) • fulvestrant
23d
Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors (clinicaltrials.gov)
P2, N=20, Active, not recruiting, University of Washington | Trial completion date: Sep 2027 --> Jul 2026 | Trial primary completion date: Sep 2026 --> Nov 2025
Trial completion date • Trial primary completion date
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Verzenio (abemaciclib)
23d
Safety and Efficacy of SPH4336 in Combination With Endocrine Therapy in the Treatment of Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov)
P2/3, N=254, Recruiting, Shanghai Pharmaceuticals Holding Co., Ltd | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
Trial completion date • Trial primary completion date
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fulvestrant • SPH4336