Chronic Myeloid Leukemia

The DSN integrates dual functionalities: a highly specific recognition probe for the BCR-ABL fusion gene, and a peroxidase-mimetic nanozyme that catalyzes the 3,3',5,5'-tetramethylbenzidine (TMB)-H2O2) redox reaction, producing both visible colorimetric signals and quantifiable photothermal effects. This strategy enables sensitive detection of the BCR-ABL fusion gene, providing a valuable tool for the early diagnosis and minimal residual disease monitoring of chronic myeloid leukemia.

P1/2, N=30, Active, not recruiting, M.D. Anderson Cancer Center | Recruiting --> Active, not recruiting | N=80 --> 30

P=N/A, N=100, Enrolling by invitation, Qian Jiang

P=N/A, N=38, Recruiting, University of Wisconsin, Madison | Not yet recruiting --> Recruiting

An increased prevalence of second primary malignancy is anticipated due to the rising cancer burden and the careful screening of index initial malignancy throughout therapy. Determining the best course of action requires careful staging of the cancer and discussion by a multidisciplinary team.

Pathway analyses highlighted membrane-proximal processes (external plasma membrane and IgG binding) and a 16p11.2 signal. This integrative analysis identified CCR2-ARTN as a mechanistically supported immune-inflammation axis contributing to AML risk, offering a potential therapeutic target and warrants direct validation in primary CD62L + myeloid DCs.

Betamethasone and levofloxacin ophthalmic solutions were started on the same day. Molecular remission was achieved on day 161 after relapse. Three years later, the patient remains in remission on dasatinib therapy.

P=N/A, N=266, Recruiting, Canadian Cancer Trials Group | Trial completion date: Dec 2025 --> Jun 2027 | Trial primary completion date: Dec 2025 --> Dec 2026

Finally, the duplex FA-eLCR successfully detected the BCR/ABL1p210 transcripts in patients with chronic myeloid leukemia (CML) and monitored the change of transcripts during treatment, with 100 % concordance to reverse transcription-quantitative polymerase chain reaction, highlighting its high potential in the early diagnosis and minimal residual disease (MRD) monitoring of CML. This work presents a novel strategy to address nonspecific amplification in LCR and introduces a cost-effective, highly sensitive platform for molecular diagnosis in clinical setting.

P=N/A, N=1, Completed, The First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University

P=N/A, N=100, Not yet recruiting, Peking University People's Hospital; Peking University People's Hospital

Quantitative three-dimensional imaging approaches are also applied to craniofacial surgery, where cone-beam computed tomography-based analyses identify determinants of lip cant and facial midline correction following bimaxillary surgery. A conceptual synthesis places living systems and learning systems within shared theoretical frameworks, highlighting the convergence of physics, information theory, and artificial intelligence in understanding biological organization.