Colorectal Cancer

P=N/A, N=50, Recruiting, Centre Paul Strauss | Trial completion date: Sep 2026 --> Jul 2030

P=N/A, N=546, Enrolling by invitation, Indiana University | Not yet recruiting --> Enrolling by invitation

P3, N=700, Recruiting, AbbVie | Not yet recruiting --> Recruiting

The DKK4-based risk prediction model shows moderate predictive value for 1-3-year short-term survival in CRC patients. DKK4 exhibits a stage-specific expression pattern during colorectal tumorigenesis and primarily acts in the precancerous stage of adenoma-carcinoma transition, which makes it a potential specific biomarker for CRC precancerous lesion screening, providing a new molecular target for early CRC screening and intervention.

In colon cancer, the adverse prognostic signal within T4N0 disease appears to be driven primarily by T4bN0. These findings support reconsideration of current staging paradigms, particularly for T4bN0 colon cancer, and warrant further prospective validation of risk-adapted postoperative strategies.

CRNDE 84aa is highly expressed in breast cancer and functions as a tumor antigen that activates anti-tumor immunity. This study suggests that lncRNA-encoded peptides represent a viable source of tumor antigens for immunologically "cold" tumors such as breast cancer, highlighting their potential as novel targets for immunotherapy.

Notably, elevated miR-501 expression was associated with more than a twofold increased risk of death in stage IV CRC patients from the TCGA-COAD cohort. IL-17 signaling may drive CRC progression and poor clinical outcomes in part through the induction of miR-501-5p, underscoring its potential role in immune-related cancer metastasis and as a prognostic biomarker.

Targeting the Fn-NF-κB-MMPs pathway could represent a novel therapeutic strategy for preventing CRC metastasis. Additionally, Fn abundance may serve as a potential biomarker for CRC diagnosis or prognosis.

The model showed acceptable discrimination and calibration in the SEER-derived cohorts, and external calibration showed generally acceptable agreement in the preliminary external validation cohort. Further validation in larger multicenter cohorts is needed.

Moreover, MALINC1 knockdown enhanced the sensitivity of these cells to platinum-based drugs. These findings suggest that a prognostic model based on six key disulfidptosis-related lncRNAs holds potential for predicting outcomes in patients with COAD, and that targeting MALINC1 may offer new insights into colorectal cancer chemotherapy.

Mechanistically, curcumin lowered IKKβ expression, attenuated NF-κB p65 phosphorylation, and down-regulated Snail protein. Collectively, these results indicate that curcumin curtails CRC cell migration, at least in part, through suppression of the IKKβ/NF-κB/Snail-driven EMT program, thereby providing a mechanistic rationale for its further preclinical and clinical evaluation as an adjunctive anti-metastatic approach in CRC.

Exogenous ACSL3 expression rescued the tumor-suppressive effects caused by YTHDF1 silencing. YTHDF1 enhances ACSL3 translation in an m6A-dependent manner to promote lipid metabolism, thereby facilitating the progression of READ.