P2, N=240, Not yet recruiting, ZetrOZ, Inc.

P3, N=354, Active, not recruiting, SWOG Cancer Research Network | Trial primary completion date: Feb 2027 --> Sep 2027

In mice with gastric ulcers, EA combined with Ome can better repair indomethacin-induced gastric injury via inactivation of macrophages and Nrf2-mediated antioxidant signaling pathway, which is primarily mediated by vagus nerve.

The standard treatment is low-dose aspirin and phlebotomy, with cytoreductive therapy added for high-risk PV. All 3 patients achieved and maintained complete hematologic response with reduced JAK2 V617F allele burden. Ropeg-IFN is an effective and safe therapy for elderly patients with PV that also improves quality of life.

Although thrombosis prevention is crucial in ET, anagrelide is associated with a higher risk of bleeding events than other therapies. To our knowledge, this is the first reported case of gastric intramural hematoma associated with ET and anagrelide.

P4, N=137, Completed, Children's Mercy Hospital Kansas City | Active, not recruiting --> Completed

P3, N=11000, Active, not recruiting, University College, London | Not yet recruiting --> Active, not recruiting

P1/2, N=60, Recruiting, Fundacion Instituto De Investigacion Sanitaria Aragon | Not yet recruiting --> Recruiting

P3, N=137, Completed, Royal College of Surgeons, Ireland | N=300 --> 137 | Unknown status --> Completed

P=N/A, N=300, Recruiting, Tang-Du Hospital

Complexes based on naproxen, ibuprofen, and salicylic acid derivatives display potent antiproliferative activity against Caco-2/TC7 colon cancer cells, outperforming oxaliplatin and being comparable to auranofin, while showing markedly reduced cytotoxicity in breast cancer lines and nonmalignant cells, thus indicating promising selectivity. Additionally, complex 1 selectively inhibits the enzyme cyclooxygenase-2 (COX-2) over COX-1 and reduces IL-8 expression without affecting PTGS2 transcription, highlighting a post-transcriptional anti-inflammatory action. These results support NSAID-derived alkynyl gold(I) complexes as promising multitarget agents for colorectal cancer intervention, combining disruption and COX-2 modulation.

The PEAR1/EAF1 interaction ameliorates aspirin resistance in atherosclerosis. This effect is associated with suppression of the endothelial NF-κB/NLRP3 inflammatory signaling pathway and altered endothelial cell fate under inflammatory stress. Targeting the PEAR1/EAF1 interaction represents a novel potential therapeutic strategy for overcoming AR.