Cutaneous T-cell Lymphoma

The finding of this cohort study suggest that adult HMF demonstrated a generally indolent course, with favorable response to skin-directed therapy, irrespective of immunophenotype or mixed-variant presentation. Peripheral blood TCR monoclonality was associated with lower treatment response but not disease progression.

P1, N=45, Active, not recruiting, Baylor College of Medicine | Recruiting --> Active, not recruiting | N=27 --> 45 | Trial completion date: May 2040 --> Mar 2041

Given the lesion's location in a cosmetically sensitive area, care was coordinated with dermatology, hematology/oncology, and plastic surgery. This case highlights the importance of clinicopathologic correlation in distinguishing PCSM-TCLPD from its malignant mimickers and in guiding appropriate management.

P1/2, N=78, Recruiting, City of Hope Medical Center | Active, not recruiting --> Recruiting | N=38 --> 78

P1, N=10, Suspended, University of Alabama at Birmingham | Trial completion date: Jul 2026 --> Jul 2027 | Recruiting --> Suspended | Trial primary completion date: Apr 2026 --> Jun 2027

P2, N=30, Completed, Northwestern University | Active, not recruiting --> Completed

BV is a key therapy for CD30-positive CTCL. While real-world experience suggests potential activity in CD30-negative or low disease, prospective trials are needed to define its role in this challenging subgroup.

Resiquimod suppressed B16 melanoma growth, with an effect superior to that of imiquimod...In patient-derived organoids and melanoma slice cultures, resiquimod induced significant tumor killing and CD8+ T cell activation, further augmented by PD-1 antibodies. Our findings support the conclusion that resiquimod promotes CD8+ T-cell priming via dendritic cells and enhances the therapeutic efficacy of anti-PD-1 checkpoint blockade in melanoma.

P1, N=42, Recruiting, University of Pennsylvania | Not yet recruiting --> Recruiting

In both cases, the epidermotropic infiltrate was CD8-positive T-cell dominant, accompanied by scarce FOXP3-positive cells and increased expression of CXCL10 together with CCL19. These shared features support the concept that a Tc1-associated cytotoxic immune milieu, accompanied by scarce FOXP3-positive cells, may be associated with hypopigmentation in hypopigmented MF, irrespective of the age at clinical presentation.