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    GENE:

    EGR1 (Early Growth Response 1)

    i
    Other names: EGR1, Early Growth Response 1, Nerve Growth Factor-Induced Protein A, Early Growth Response Protein 1, Transcription Factor ETR103, Zinc Finger Protein 225, Transcription Factor Zif268, Zinc Finger Protein Krox-24, NGFI-A, ZNF225, AT225, EGR-1, KROX-24, ZIF-268, KROX24, G0S30, TIS8
    Associations

    News

    Trials
    6d
    EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma. (PubMed, Transl Oncol)
    We defined a novel ISG signature in iCCA and identified EGR1 as a critical driver of senescent tumor cells in iCCA.These findings offer new insights into senescent tumor cells and the immunosuppressive microenvironment.
    Journal
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    CXCL12 (C-X-C Motif Chemokine Ligand 12) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • EGR1 (Early Growth Response 1) • LGALS9 (Galectin 9)
    6d
    Distinct periarticular muscle transcriptomes: inflammation in rheumatoid arthritis versus metabolic dysregulation in osteoarthritis. (PubMed, Clin Exp Rheumatol)
    This study reveals distinct molecular pathologies in the periarticular muscle of RA and OA. RA muscle shows an intense inflammatory profile potentially linked to cachexia, whereas OA muscle displays features of metabolic disease and pro-fibrotic remodelling.
    Journal
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    IL6 (Interleukin 6) • IL2 (Interleukin 2) • EGR1 (Early Growth Response 1) • SFRP4 (Secreted frizzled-related protein 4)
    16d
    Programmed death-ligand 1 nuclear translocation: A novel perspective from membrane localization to nuclear function. (PubMed, Int J Cancer)
    This review systematically summarizes the molecular mechanisms underlying PD-L1 nuclear translocation, its biological functions, roles within the tumor microenvironment, and potential as a biomarker and therapeutic target. Emphasis is placed on addressing functional heterogeneity and mitigating experimental artifacts, which is critical for translational research.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • HIP1 (Huntingtin Interacting Protein 1) • VIM (Vimentin) • HDAC2 (Histone deacetylase 2) • EGR1 (Early Growth Response 1)
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    PD-L1 expression
    26d
    A Computational Strategy to Identify Hub Genes in Pathway Analysis of Gamma Tocotrienol-treated MCF-7 Cells and Molecular Docking Study Using Selected Phytochemicals as Therapeutic Agents. (PubMed, Curr Med Chem)
    These findings may facilitate the development of traditional medicinebased therapeutic strategies and provide insights for potential lead optimization in breast cancer drug discovery.
    Journal
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    EGR1 (Early Growth Response 1)
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    Piqray (alpelisib) • Truqap (capivasertib) • Orserdu (elacestrant) • Legalon (silibinin)
    29d
    Heterogeneity and regulatory mechanisms of ALK-mutant and wild-type epithelial cells in non-small-cell lung cancer: Single-cell transcriptomics and chromatin accessibility. (PubMed, Pharmacology)
    ALK mutations drive tumor stemness and drug resistance by blocking epithelial cell differentiation, activating CEACAM6-mediated signaling, enhancing chromatin accessibility, and remodeling the EGR1/PRC regulatory network. Targeting CEACAM6 and its downstream effector EGR1 may represent an effective strategy to overcome ALK-TKI resistance.
    Journal
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    ALK (Anaplastic lymphoma kinase) • CEACAM5 (CEA Cell Adhesion Molecule 5) • CEACAM6 (CEA Cell Adhesion Molecule 6) • SPINK1 (Serine peptidase inhibitor, kazal type 1) • EGR1 (Early Growth Response 1) • MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate)
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    ALK mutation
    1m
    EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease. (PubMed, Exploration (Beijing))
    Disruption of EGR1 phase separation significantly alleviated cyst growth in the forskolin-induced 3D spheroid model of mIMCD3 cells and MDCK cyst model. These findings demonstrate that phase separation-mediated EGR1 condensates facilitate renal cyst development in ADPKD.
    Journal
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    CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • CDK4 (Cyclin-dependent kinase 4) • YAP1 (Yes associated protein 1) • EGR1 (Early Growth Response 1)
    1m
    Combinational Inhibition of the eIF4F Complex, AKT1, and EZH2 Enhances Anticancer Effects in BRAFV600E Mutant A375 Melanoma Cells. (PubMed, Oncol Res)
    Melanoma A375 (vemurafenib [VEM]-sensitive) and A375R (VEM-resistant) cells were exposed to eIF4Fi RocA at varying doses and durations in vitro...Combined CR-1-31-B, EZH2i, and AKT1i effectively overcame resistance to RocA and VEM resistance both in vitro and in vivo. The eIF4F complex inhibitor reactivates ERK1/2-EZH2 and AKT1 signaling pathways, resulting in resistance to both eIF4Fi and VEM. Combined administration of an eIF4Fi with EZH2 and AKT1 inhibitors effectively enhances sensitivity to both eIF4F complex and BRAF inhibitors.
    Journal • IO biomarker
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • MCL1 (Myeloid cell leukemia 1) • EGR1 (Early Growth Response 1) • EIF4G1 (Eukaryotic translation initiation factor 4 gamma, 1) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • JUN (Jun proto-oncogene)
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    BRAF V600E • BRAF V600
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    Zelboraf (vemurafenib) • CR-1-31-B
    1m
    Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice. (PubMed, Part Fibre Toxicol)
    Pharmacological inhibition or genetic knockout of Padi2 attenuated silica-induced lung inflammation and fibrosis. These findings suggest that targeting PADI2 may represent a novel therapeutic strategy of silicosis.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • VIM (Vimentin) • IL1B (Interleukin 1, beta) • EGR1 (Early Growth Response 1)
    1m
    Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. (PubMed, Front Cell Infect Microbiol)
    To explore potential therapeutic interventions, we performed small-molecule drug prediction and molecular docking for hub genes revealed: Simvastatin: Linked to CCL20, NFKBIA, and ICAM1. Atorvastatin: Associated with CDKN1A, ICAM1, and TNF. TPCA-1: Targeting JAK1. These findings provide a theoretical foundation for further investigation into the molecular mechanisms underlying H. pylori-related diseases.
    Journal
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    BRCA1 (Breast cancer 1, early onset) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • BIRC3 (Baculoviral IAP repeat containing 3) • JAK1 (Janus Kinase 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • CCL20 (C-C Motif Chemokine Ligand 20) • ICAM1 (Intercellular adhesion molecule 1) • IRF1 (Interferon Regulatory Factor 1) • ITGAM (Integrin, alpha M) • SPI1 (Spi-1 Proto-Oncogene) • ETS1 (ETS Proto-Oncogene 1) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • NFKBIA (NFKB Inhibitor Alpha 2) • NFKBIE (NFKB Inhibitor Epsilon) • TRAF1 (TNF Receptor Associated Factor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • E2F1 (E2F transcription factor 1) • EGR1 (Early Growth Response 1) • HSF1 (Heat Shock Transcription Factor 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)
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    simvastatin • atorvastatin
    1m
    Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation. (PubMed, Gastro Hep Adv)
    Fasting-induced hepatic lipid accumulation indeed indicated reduced fatty acid oxidation efficiency upon ablation of EGR1. Hepatic EGR1 deficiency significantly alters lipid metabolism and mitochondrial function, indicating a role of EGR1 in regulating the balance between mitochondrial fatty acid β-oxidation and respiration in the liver.
    Journal
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    EGR1 (Early Growth Response 1)
    1m
    Glycolytic-inflammatory crosstalk mediated by Glyco-PMF-Rux hub genes drives PMF progression and ruxolitinib resistance. (PubMed, Genes Genomics)
    STAT1, EGR1, FOXO1, and SMAD7 are associated with glycolytic-inflammatory crosstalk underlying PMF progression and ruxolitinib resistance, with experimental validation supporting STAT1 and EGR1 as potential diagnostic and therapeutic targets.
    Journal
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    STAT1 (Signal Transducer And Activator Of Transcription 1) • SMAD7 (SMAD Family Member 7) • EGR1 (Early Growth Response 1)
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    Jakafi (ruxolitinib)