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    DRUG CLASS:

    Estrogen receptor agonist

    Related drugs:
    18d
    Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial (clinicaltrials.gov)
    P2, N=58, Recruiting, University of Utah | Trial completion date: Apr 2027 --> Jan 2029 | Trial primary completion date: Dec 2026 --> Jul 2028
    Trial completion date • Trial primary completion date
    20d
    An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin (clinicaltrials.gov)
    P1, N=24, Completed, Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | Recruiting --> Completed
    Trial completion
    27d
    Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial (clinicaltrials.gov)
    P2, N=60, Not yet recruiting, University of Washington
    New P2 trial • HEOR
    |
    AR (Androgen receptor)
    |
    Divigel (estradiol)
    2ms
    VITAL-E: Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause (clinicaltrials.gov)
    P=N/A, N=100, Recruiting, Stratpharma AG | Trial completion date: Nov 2025 --> Sep 2026 | Trial primary completion date: Nov 2025 --> Sep 2026
    Trial completion date • Trial primary completion date • Head-to-Head
    2ms
    EstraMemo: Estradiol and Intrusive Memories (clinicaltrials.gov)
    P=N/A, N=273, Recruiting, Charite University, Berlin, Germany
    New trial
    |
    estradiol valerate
    2ms
    The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface. (clinicaltrials.gov)
    P=N/A, N=90, Completed, Cairo University
    New trial
    2ms
    Estradiol replacement attenuates alendronate-associated adverse effects on alveolar bone repair in ovariectomized rats. (PubMed, J Periodontol)
    Osteoporosis is common in postmenopausal women due to reduced estrogen levels and leads to weaker bones. Alendronate is widely prescribed to lower fracture risk, but it may interfere with bone healing after dental procedures such as tooth extraction. Using a rat model that mimics postmenopausal bone loss, this study examined how estrogen deficiency, alendronate treatment, and estrogen replacement together influence healing of the tooth socket, a process highly relevant to periodontal and oral surgical care. The results showed that estrogen deficiency alone already compromised bone repair, and this effect became more pronounced when alendronate was used. Estrogen replacement with estradiol valerate did not fully restore normal healing, but it reduced several harmful changes in bone structure and local inflammatory activity associated with alendronate. Importantly, no bone necrosis was observed under the conditions studied, although persistent disturbances in bone remodeling were evident. These findings help clarify how systemic bone conditions and osteoporosis treatments can influence periodontal wound healing and support more informed risk assessment and interdisciplinary planning when dental extractions are required in patients with osteoporosis.
    Preclinical • Journal • Adverse events
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B) • TNFSF11 (TNF Superfamily Member 11)
    |
    estradiol valerate
    2ms
    Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery (clinicaltrials.gov)
    P4, N=38, Terminated, University of Alabama at Birmingham | Trial completion date: Jul 2026 --> Feb 2026 | Recruiting --> Terminated; Ran out of funding
    Trial completion date • Trial termination
    2ms
    CC-OVI: Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (clinicaltrials.gov)
    P=N/A, N=90, Completed, Yuzuncu Yil University
    New trial
    2ms
    Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder (clinicaltrials.gov)
    P4, N=30, Completed, Mahidol University | Not yet recruiting --> Completed
    Trial completion
    2ms
    Impact of Estradiol on Endothelial Function in Peri-Menopausal Women (clinicaltrials.gov)
    P4, N=80, Active, not recruiting, University of Delaware | Recruiting --> Active, not recruiting | Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2025 --> May 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    2ms
    A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases (clinicaltrials.gov)
    P2, N=24, Not yet recruiting, Universiti Kebangsaan Malaysia Medical Centre | Initiation date: Jul 2025 --> Feb 2026
    Trial initiation date
    |
    estradiol valerate