These results suggest that amodiaquine derivatives have anti-COAD actions due to their disruption of important immune-regulatory and apoptotic pathways. These findings computationally prioritize amodiaquine and desethylamodiaquine as candidate multi-target interactors in colon adenocarcinoma, warranting further experimental investigation rather than implying established therapeutic efficacy.

24 days ago

Journal

SYK (Spleen tyrosine kinase) • KCNH2 (Potassium Voltage-Gated Channel Subfamily H Member 2)

25d

APP: A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults (clinicaltrials.gov)

P1, N=24, Not yet recruiting, University of Oxford

25 days ago

New P1 trial

2ms

90301900HNC1001: A Study of JNJ-90301900 in Combination with Concurrent Chemoradiation Therapy in LA HNSCC (2025-522914-22-00)

P1, N=8, Recruiting, Janssen Cilag International

2 months ago

New P1 trial

Hensify (crystalline hafnium oxide)

2ms

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies (clinicaltrials.gov)

P1/2, N=40, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Feb 2026 --> Feb 2028 | Trial primary completion date: Feb 2026 --> Feb 2028

2 months ago

Trial completion date • Trial primary completion date

Hensify (crystalline hafnium oxide)

2ms

OPTIMAH: OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa (clinicaltrials.gov)

P4, N=380, Recruiting, Yale University | Not yet recruiting --> Recruiting

2 months ago

Enrollment open

2ms

Elucidation of a Novel Protective Function of AADAC Against Drug-induced Liver Injury through Ferroptosis Suppression (PubMed, Yakugaku Zasshi)

Using Aadac knockout (KO) mice, we demonstrated that CCl4, APAP, and amodiaquine induced more severe liver damage in the absence of Aadac, with elevated ferrous (Fe2+) levels, lipid peroxidation, and oxidative stress...Furthermore, human AADAC overexpression in Huh-7 cells similarly reduced intracellular Fe2+ levels and conferred protection against CCl4-induced cytotoxicity in a ceruloplasmin-dependent manner. These findings reveal a novel, non-catalytic role for AADAC in iron homeostasis and ferroptosis suppression, suggesting its clinical significance in DILI susceptibility and therapy.

2 months ago

Review • Journal

AADAC (Arylacetamide Deacetylase)

2ms

NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer (clinicaltrials.gov)

P2, N=14, Terminated, M.D. Anderson Cancer Center | Trial completion date: Sep 2026 --> Jan 2026 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2026 --> Jan 2026; <75% participation

2 months ago

Trial completion date • Trial termination • Trial primary completion date • IO biomarker

PD-L1 (Programmed death ligand 1)

Keytruda (pembrolizumab) • Hensify (crystalline hafnium oxide)

3ms

ALAQ: Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects (clinicaltrials.gov)

P1, N=8, Terminated, University of Oxford | N=16 --> 8 | Trial completion date: Aug 2026 --> Apr 2025 | Recruiting --> Terminated | Trial primary completion date: Aug 2026 --> Apr 2025; The decision was made due to the expired investigational drug and regulatory changes by the Thai FDA, along with increased importation costs. The research team and investigational drug sponsor agreed to seek approval for early project termination.

3 months ago

Enrollment change • Trial completion date • Trial termination • Trial primary completion date

3ms

PMC-VAC: Perennial Malaria Chemoprevention in the Malaria Vaccine Era (clinicaltrials.gov)

P4, N=1290, Not yet recruiting, Stanford University

3 months ago

New P4 trial

4ms

LUMIRAY: A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov)

P1, N=30, Recruiting, Johnson & Johnson Enterprise Innovation Inc. | Not yet recruiting --> Recruiting

4 months ago

Enrollment open

Hensify (crystalline hafnium oxide)