Gallbladder Cancer

P2, N=58, Active, not recruiting, University of Texas Southwestern Medical Center | Trial completion date: Jun 2027 --> Jun 2028 | Trial primary completion date: Jul 2026 --> Jul 2027

The presence of morules, which display nuclear β-catenin expression, places this lesion in the so-called BROCN family of tumors, which are believed to be hormonally driven. Further molecular studies are needed to explore the roots of their behavior.

This study establishes a fully automated CT-based deep learning pipeline for HER2 status prediction in unresectable GBC. Validation in larger, multi-institutional cohorts is warranted.

P2, N=107, Active, not recruiting, Tianjin Medical University Cancer Institute and Hospital

P1, N=24, Recruiting, Ruijin Hospital

P2, N=30, Not yet recruiting, HuiKai Li

In this review, we integrate evidence from hepatocellular carcinoma, pancreatic ductal adenocarcinoma, cholangiocarcinoma, colorectal cancer, gastric cancer, esophageal cancer, and gallbladder cancer within a unified framework that links KMT2C domain architecture to enhancer-network destabilization, phenotypic state transitions, and clinical manifestations. We further propose a functional evaluation paradigm that reframes discrete KMT2C variants as graded states of epigenetic deficiency, coupled with a closed-loop validation strategy integrating tissue-based profiling, liquid biopsy monitoring, and spatial multi-omics analyses.

We demonstrated the real-world genomic characteristics of BTC patients, which may have promising implications for the development and application of precision medicine in the future. Well-designed prospective studies are mandatory to validate the predictive role of significant genomic alterations observed in our study.

In vivo experimental results demonstrated that ω-3PUFAs significantly inhibited the growth of gallbladder cancer xenografts, with tumor growth inhibition rates of 38.6% for GBC-SD and 50.2% for NOZ at day 33, and effectively suppressed tumor cell metastasis in an intraperitoneal mouse model. This study provides first evidence that ω-3PUFAs target STK31 via epigenetic reprogramming, opening new avenues for dietary intervention and targeted therapy of GBC.

P3, N=195, Recruiting, InnoPharmax Inc. | Not yet recruiting --> Recruiting

P1/2, N=30, Recruiting, Beijing Biotech

Tumor size and grade may help predict metastatic potential, while the relatively frequent paraganglioma-like morphology, often associated with diffuse somatostatin expression, can represent a diagnostic pitfall. Their frequent association with cholesterol polyps also suggests a possible etiopathogenetic link.