Gastric Adenocarcinoma

P1, N=260, Not yet recruiting, IDEAYA Biosciences

ACC and DLBC shared a consensus expression program, whereas STAD diverged; chromatin analysis showed AP-2 motifs near microbe-responsive genes in ACC and DLBC but not STAD, supporting cohort-specific regulation. Collectively, AP-2 family members emerge as plausible mediators of tumor microbiota-host interplay, warranting further mechanistic and translational research.

P=N/A, N=2000, Enrolling by invitation, Nanfang Hospital, Southern Medical University

It also shows positive expression of gastric-type markers such as MUC6, Mucin 5AC, and HIK1083. Imaging examination revealed the size of the lesion, depth of infiltration, the invasion of adjacent organs, and lymph node metastasis, which is beneficial for differential diagnosis, clinical staging, and the development of a treatment plan.

These findings suggest that ITPRIPL1 is a potential prognostic marker and immunosuppressive target in STAD.

P3, N=204, Completed, Shanghai Cancer Hospital, China | Recruiting --> Completed | N=682 --> 204

P3, N=324, Not yet recruiting, Federation Francophone de Cancerologie Digestive

in order to capture intratumoral heterogeneity and evolving molecular events. Further investigation of FGFR2 fusion biology and combinatorial therapeutic strategies is warranted to address the clinical challenge of biomarker overlap and treatment resistance in GEA.

Subsequently, the patient was treated with an innovative regimen consisting of endoscopic intratumoral injections of Oncolytic adenovirus H101 in combination with the PD-1 inhibitor tislelizumab...The patient achieved nearly 4 months of progression-free survival and a substantial improvement in quality of life. This case highlights the potential of combining oncolytic virotherapy with PD-1 inhibition as a promising and novel personalized strategy for treating elderly patients with advanced gastrointestinal cancers who are unsuitable candidates for conventional therapies.

This pan-cancer study elucidates the pivotal role of ENTPD6 in tumor progression and establishes its potential as a therapeutic target for immunotherapeutic approaches in specific malignancies.

CDN inhibits GA by functionally modulating c-Myc/GLUT4/PGC-1α axis mediated glucose uptake and energy metabolism reprogramming, implicating its potential for GA chemotherapy.

P2, N=30, Not yet recruiting, Shanghai Zhongshan Hospital