Gastrointestinal Cancer

These findings suggest that EIN during chemotherapy enhances nutritional and immune status, reduces inflammation, and improves QoL, warranting further large-scale trials to confirm its benefits in cancer care.

Laparoscopic surgery in our case provided the patient with quick recovery and a less invasive approach with satisfying results and the absence of recurrent disease during a one-year follow-up period. Future multicenter studies should facilitate a deeper comprehension and undoubtedly lead to a more effective management of a rare and enigmatic condition that is uterine PEComa.

This review examines MDK's molecular and biological functions in gastrointestinal cancers, emphasizing its clinical utility in diagnosis, prognosis, and therapy. By exploring the intricate mechanisms of MDK, this study aims to advance the development of novel, personalized therapeutic strategies to improve patient outcomes.

In heavily pretreated patients with advanced solid tumors, E7386 demonstrated a manageable safety profile and a dose-dependent PK profile. PRs were noted in patients with small bowel carcinoma or desmoid tumor.

Next-generation sequencing of the primary small intestinal tumor identified pathogenic mutations in PTEN, TP53, ataxia telangiectasia mutated, ephrin type-A receptor 5 and EGFR p.F997L, suggesting a DNA-repair-deficient genomic background and providing potential targets for future precision therapy. Further research is warranted to determine the molecular mechanisms underlying SMARCA4-DUC, for the development of targeted therapeutic strategies and to improve the understanding of the aggressiveness of SMARCA4-DUC.

Although inflammatory markers showed limited overall correlations, the PLR-PNI relationship and reduced PNI in necrotic tumors suggest that inflammation and nutritional decline may reflect tumor aggressiveness in small bowel GISTs. Larger studies are needed to confirm these findings.

In the literature, Cowden syndrome has been associated with breast cancer, thyroid cancer, endometrial cancer and a very small percentage of melanomas. However, this is the first report of Cowden syndrome that has been diagnosed after an early-onset superficial spreading melanoma.

P1, N=18, Recruiting, Shanghai Juncell Therapeutics | Trial primary completion date: Nov 2025 --> Nov 2026

The nomogram had an AUC of 0.977 and proved clinically useful. The GALADM model, combining miRNA7 with the GALAD model, surpasses the original GALAD model, enabling early-stage and AFP-negative HCC diagnosis.

Primary gallbladder EGISTs are exceedingly rare, with insidious onset and nonspecific clinical manifestations. Histopathological examination combined with immunohistochemistry remains the cornerstone of definitive diagnosis.

By inducing synergistic cell death and immune activation, this strategy provides a foundation for clinical translation and identifies novel molecular targets for future investigation. Our findings underscore the feasibility of engineered oral OV formulations to improve treatment outcomes in intestinal malignancies.

Standardizing sampling, sequencing, and analytical methodologies remains a critical challenge. The incorporation of microbiome profiling into diagnostic and registry systems could enable routine use of intratumoral microbial signatures as prognostic biomarkers, paving the way toward microbiome-informed precision oncology.