^
    1d
    Hybrid Dissolving Microneedles Incorporating Hyaluronic Acid Microdepots for Pain-free and Long-acting Corticosteroid Therapy. (PubMed, Biomater Res)
    This study presents a long-acting hybrid dissolving microneedle (DMN) patch incorporating hyaluronic acid (HA)-based microparticle depots (TA@MDepots) for intradermal delivery of triamcinolone acetonide (TA)...Histological analyses confirm skin structure restoration and immune modulation, while systemic toxicity assessments show no adverse effects. This hybrid DMN platform offers a minimally invasive, biocompatible, and patient-friendly strategy for prolonged corticosteroid delivery in chronic inflammatory skin diseases and represents a promising alternative to conventional topical or injectable therapies.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha)
    1d
    Local Methotrexate Injections for the Treatment of Nail Psoriasis (clinicaltrials.gov)
    P4, N=1, Terminated, Weill Medical College of Cornell University | Active, not recruiting --> Terminated; The study was terminated due to slow accrual.
    Trial termination
    2d
    Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study) (clinicaltrials.gov)
    P=N/A, N=200, Recruiting, Chulalongkorn University | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Nov 2026
    Trial completion date • Trial primary completion date
    |
    dexamethasone
    2d
    The ASPIRE Trial: AchilleS tendinoPathy Treated With cortIcosteRoid injEctions. (clinicaltrials.gov)
    P3, N=276, Recruiting, Erasmus Medical Center
    New P3 trial
    |
    methylprednisolone acetate
    2d
    Clinical and immunological effects of adding cyclophosphamide to pomalidomide-dexamethasone in relapsed-refractory multiple myeloma: The randomized MUKseven trial. (PubMed, Br J Haematol)
    Pretreatment CD4+ T-cell levels were identified as a prognostic PFS marker. In summary, our results demonstrate significant effects of cycloaddition to Pd on response and T-cell composition.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    cyclophosphamide • dexamethasone • pomalidomide
    3d
    Stress-Induced Changes in the Methylation Status of Mmp1 and Mmp8 Genes in Tumor Tissue of Rats with Guerin Carcinoma. (PubMed, Exp Oncol)
    Our study demonstrated that chronic glucocorticoid-induced stress altered the epigenetic profile of tumor cells by in- ducing differential methylation of the matrix metalloproteinase genes. Specifi  ally, it promoted the maintenance of Mmp1 hypomethylation and signifi  antly increased the Mmp8 promoter hypermethylation. These fi  dings suggest that chronic stress may contribute to an aggressive tumor phenotype through the epigenetic regulation of extracel- lular matrix remodeling.
    Preclinical • Journal
    |
    MMP1 (Matrix metallopeptidase 1) • MMP8 (Matrix Metallopeptidase 8)
    |
    dexamethasone
    6d
    Paraneoplastic neurologic syndrome in advanced lung cancer with mixed adenocarcinoma and squamous features: a diagnostic challenge-a case report. (PubMed, J Med Case Rep)
    This case highlights the diagnostic challenges of antibody-negative paraneoplastic neurologic syndromes. The study underscores the important role of PET-CT in identifying occult malignancy and the role of repeat biopsy in progressive disease. Discordant histologic findings should be interpreted cautiously, as they may reflect tumor heterogeneity or possible adenosquamous carcinoma rather than true histologic evolution. Limited molecular testing, and sampling constraints remain important challenges, particularly in resource-limited settings.
    Journal
    |
    TTF1 (Transcription Termination Factor 1) • NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63)
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    carboplatin • pemetrexed • methylprednisolone sodium succinate
    7d
    RESPOND Study: Assessing the Efficacy of Treatment with Vitamin C and Hydrocortisone in Children Admitted to Intensive Care Unit with Septic Shock. (ACTRN12621000247875)
    P2, N=384, Active, not recruiting, The University of Queensland | Recruiting --> Active, not recruiting
    Enrollment closed
    7d
    DEXA-SEPSIS: Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis (clinicaltrials.gov)
    P1/2, N=102, Completed, CHA University | Recruiting --> Completed
    Trial completion
    |
    dexamethasone injection
    8d
    ABCD: Dexamethasone in Controlling Dyspnea in Patients With Cancer (clinicaltrials.gov)
    P2, N=135, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2025 --> Dec 2028
    Trial completion date
    8d
    Anesthetic Block of the Erector Muscles of the Lumbar Spine to Relieve Acute Lumbar Pain: Pilot Study (clinicaltrials.gov)
    P3, N=40, Recruiting, Elsan | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone injection
    8d
    Epidural Steroid Injection for Restless Legs Symptoms in Lumbar Stenosis (clinicaltrials.gov)
    P=N/A, N=45, Completed, Saglik Bilimleri Universitesi
    New trial
    |
    dexamethasone injection