Avastin (bevacizumab) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • carboplatin • gemcitabine • Enhertu (fam-trastuzumab deruxtecan-nxki) • capecitabine • Verzenio (abemaciclib) • albumin-bound paclitaxel • Kisqali (ribociclib) • fulvestrant • eribulin mesylate • letrozole • ipatasertib (RG7440) • Trodelvy (sacituzumab govitecan-hziy) • Itovebi (inavolisib) • giredestrant (RG6171) • Actemra IV (tocilizumab) • atirmociclib (PF-07220060) • ladiratuzumab vedotin (SGN-LIV1A) • selicrelumab (RG7876)

Acute Abdomen Secondary to Ileal Perforation As the Initial Presentation of Advanced Müllerian Malignancy With Hepatic Metastasis: A Case Report. (PubMed, Cureus)

The patient received combination chemotherapy with gemcitabine, carboplatin, and bevacizumab, achieving a near-complete metabolic response. Immunohistochemistry plays a crucial role in identifying the primary tumor origin. Management requires a staged approach with emergency surgical intervention followed by multidisciplinary oncological treatment for optimal outcomes.

1 day ago

Journal

PAX8 (Paired box 8)

Avastin (bevacizumab) • carboplatin • gemcitabine

LINC00312 increases gemcitabine sensitivity in nasopharyngeal carcinoma by recruiting PABPC1 and modulating PAX5-mediated transcription of LPLUNC1. (PubMed, NPJ Precis Oncol)

In conclusion, LINC00312 increased PAX5 mRNA stability by recruiting PABPC1, which promoted LPLUNC1 transcription to regulate sensitivity of NPC to gemcitabine. Meanwhile, PAX5 in turn transcriptionally activated LINC00312 to form a feedback axis, which further increased gemcitabine sensitivity.

1 day ago

Journal

PAX5 (Paired Box 5) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)

gemcitabine

SIAG-BTC: Sintilimab Combined With Ipilimumab (N01) Plus AG as First-line Therapy for uBTC. (clinicaltrials.gov)

P2, N=107, Active, not recruiting, Tianjin Medical University Cancer Institute and Hospital

1 day ago

New P2 trial

Yervoy (ipilimumab) • gemcitabine • Tyvyt (sintilimab) • albumin-bound paclitaxel

REVIVE: A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer (clinicaltrials.gov)

P2, N=39, Recruiting, University of Chicago | Not yet recruiting --> Recruiting

2 days ago

Enrollment open • Checkpoint inhibition

HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK (Neurotrophic receptor tyrosine kinase)

Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • Imfinzi (durvalumab) • gemcitabine • docetaxel • Cyramza (ramucirumab) • Libtayo (cemiplimab-rwlc)

Cholangiocarcinoma in the Era of Precision Medicine: Emerging Insights and Therapeutic Strategies. (PubMed, Curr Pharm Des)

Advances in molecular profiling and immunotherapy are reshaping the management of cholangiocarcinoma, enabling more personalized treatment strategies. Continued integration of precision oncology into clinical practice and prospective trials will be critical to improving outcomes for cholangiocarcinoma moving forward.

3 days ago

Journal

MSI (Microsatellite instability) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • FGFR (Fibroblast Growth Factor Receptor)

cisplatin • gemcitabine • capecitabine

Antibiotic-drug conjugates: Enhancing chemo-immunotherapy of gemcitabine for pancreatic cancer by eliminating intratumoral bacteria. (PubMed, Biomaterials)

Furthermore, bacterial elimination and tumor cell damage were accompanied by modulation of the tumor immune microenvironment, including enhanced dendritic cell maturation and increased cytotoxic CD8+ T-cell infiltration. Collectively, this AiDCs strategy provides a promising approach for the treatment of intratumoral bacteria-associated, drug-resistant malignancies.

3 days ago

Journal

CD8 (cluster of differentiation 8)

gemcitabine

Bacillus Calmette-Guérin (BCG) and Gemcitabine in People With High-Grade Non-Muscle Invasive Bladder Cancer That Came Back After BCG Treatment (clinicaltrials.gov)

P1/2, N=54, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Nov 2026 --> Nov 2027 | Trial primary completion date: Nov 2026 --> Nov 2027

3 days ago

Trial completion date • Trial primary completion date

gemcitabine

Breast 54: Focused Ultrasound and Gemcitabine in Breast Cancer (clinicaltrials.gov)

P1, N=32, Active, not recruiting, Patrick Dillon, MD | Recruiting --> Active, not recruiting

3 days ago

Enrollment closed

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)

ER positive • HER-2 negative • HER-2 negative + ER positive

MammaPrint®

gemcitabine

EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC (clinicaltrials.gov)

P2, N=58, Recruiting, Peking University Third Hospital

3 days ago

New P2 trial • IO biomarker

PD-L1 (Programmed death ligand 1)

cisplatin • gemcitabine • Loqtorzi (toripalimab-tpzi) • Padcev (enfortumab vedotin-ejfv)

Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer (clinicaltrials.gov)

P1, N=21, Suspended, City of Hope Medical Center | Recruiting --> Suspended

3 days ago

Trial suspension

gemcitabine • albumin-bound paclitaxel