P3, N=150, Not yet recruiting, Assistance Publique - Hôpitaux de Paris

Nitroglycerin (glyceryl trinitrate, GTN), a nitric oxide donor, and 2-deoxy-D-glucose (2-DG), a glycolysis inhibitor, have individually demonstrated anticancer potential through modulation of cellular metabolism and redox balance. Nevertheless, these findings should be considered exploratory and hypothesis-generating because target expression, enzymatic activity, and pathway activation were not experimentally validated. Overall, the results suggest that GTN enhances caffeine-induced cytotoxicity under metabolically stressed conditions through combined metabolic and redox perturbation, although the magnitude of the response depends on cellular context and warrants further mechanistic investigation.

Our findings demonstrate that sustained astrocyte activation in TNC is a potential driver of prolonged hyperalgesia in triptan-induced MOH. Inhibiting astrocyte activity effectively reverses behavioral and molecular markers of MOH, highlighting astrocyte inhibition as a promising therapeutic strategy for MOH.

Intraoperative hypertensive crisis (blood pressure (BP) 224/120 mmHg) was managed with nitroglycerin infusion...Radical surgery with meticulous perioperative hemodynamic control is the cornerstone in recurrent/metastatic disease. Lifelong follow-up with imaging and biochemical surveillance is mandatory.

P=N/A, N=60, Not yet recruiting, Massachusetts General Hospital | Trial completion date: Dec 2027 --> Dec 2028 | Trial primary completion date: Oct 2027 --> Oct 2028

P=N/A, N=66, Completed, Zagazig University

P=N/A, N=80, The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University

P=N/A, N=74, Recruiting, Instituto Nacional de Cancerologia de Mexico | Trial completion date: Feb 2026 --> Feb 2027 | Trial primary completion date: Dec 2025 --> Dec 2026

P1, N=15, Not yet recruiting, Johns Hopkins University | Initiation date: Mar 2026 --> Nov 2026 | Trial primary completion date: Mar 2027 --> Sep 2027

P=N/A, N=80, Not yet recruiting, The University of Western Australia

P=N/A, N=80, Not yet recruiting, Cairo University

The apoptotic index and nitric oxide were identified as dominant predictors, indicating mechanistic relevance but limited clinical screening utility because these predictors require histological assessment. Overall, riociguat demonstrated significant renoprotective effects through anti-apoptotic, anti-inflammatory, and antioxidative mechanisms, and machine learning provided hypothesis-generating insight rather than a clinically deployable predictive model.