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    BIOMARKER:

    GUCY2C expression

    i
    Other names: GUCY2C, Guanylate Cyclase 2C, STAR, Guanylyl Cyclase C, STA Receptor, GUC2C, GC-C, Heat-Stable Enterotoxin Receptor, Intestinal Guanylate Cyclase, HSER, GCC, Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor), Heat Stable Enterotoxin Receptor, DIAR6, MECIL, MUCIL, HSTAR
    Entrez ID:
    2984
    1year
    Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells. (PubMed, J Immunother Cancer)
    This study demonstrated a potent GUCY2C-targeted CAR-T cell for gastrointestinal tumor therapy and highlights the importance of adequate tonic signaling for effective CAR-T cell therapy against solid tumors.
    Journal • CAR T-Cell Therapy • IO biomarker
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    GUCY2C (Guanylate Cyclase 2C)
    |
    GUCY2C expression
    2years
    Phase 2A trial of Ad5.F35-GUCY2C-PADRE vaccine for recurrence prevention in gastrointestinal (GI) adenocarcinomas post definitive surgery and adjuvant therapies. (ASCO-GI 2024)
    Study enrollment is ongoing. Clinical trial information: NCT04111172.
    Clinical • P2a data • Surgery
    |
    CD4 (CD4 Molecule) • GUCY2C (Guanylate Cyclase 2C)
    |
    GUCY2C expression