Head and Neck Cancer

P3, N=700, Recruiting, Sun Yat-sen University | Trial completion date: Nov 2032 --> Nov 2031 | Trial primary completion date: Nov 2030 --> Nov 2029

P1/2, N=429, Active, not recruiting, Genmab | Trial completion date: Feb 2026 --> Aug 2026

P=N/A, N=30, Recruiting, University of Alberta | Trial completion date: May 2026 --> Aug 2026 | Trial primary completion date: Jan 2026 --> Jun 2026

P=N/A, N=300, Recruiting, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

P=N/A, N=110, Recruiting, Fondazione del Piemonte per l'Oncologia

P1/2, N=29, Active, not recruiting, University of Colorado, Denver | Recruiting --> Active, not recruiting

The patient was treated with six cycles of rituximab-bendamustine, resulting in complete regression of the nasopharyngeal mass and reduction in splenomegaly, with minimal residual lymphadenopathy and good clinical and biological tolerance. This case highlights the importance of considering CLL in the differential diagnosis of nasopharyngeal masses and emphasizes the role of combined imaging, histology, and immunophenotyping in establishing an accurate diagnosis and guiding appropriate management.

Bioinformatic analyses further indicated that the rs4274 A allele is associated with increased MIAT expression, and higher MIAT levels correlated with higher tumor grade. In conclusion, the MIAT rs4274 A allele is linked to poorer tumor differentiation, particularly among betel-quid chewers and smokers, and elevated MIAT expression supports its potential as a biomarker of tumor aggressiveness.

Herbal agents and combination therapies, such as those containing β-carotene, isotretinoin, IFN-α 2a, and vitamin E, have shown encouraging results, although the long-term benefits remain uncertain...While chemopreventive strategies offer potential, their clinical application remains limited by inconsistent outcomes and adverse effects. Advancing this field requires the development of targeted therapies, personalised approaches based on molecular profiling, and innovative delivery systems like nanocarriers to improve therapeutic efficacy and safety.

P2/3, N=30, Not yet recruiting, Rakuten Medical Inc.

Exosomes from myogenic gene-transfected MSCs significantly enhance esophageal muscle regeneration and attenuate fibrosis after radiation-induced damage. This cell-free therapeutic approach holds potential as a novel and practical strategy for addressing radiation esophagitis in patients receiving radiotherapy for head and neck malignancies.

Functionally, DBP promoted SCC9 proliferation and reduced LPL expression, and was associated with transcriptional changes in PI3K-AKT-mTOR-related genes, whereas LPL restoration mitigated these effects. These findings reveal a novel DBP-LPL axis in HNSC.